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Identification of signature genes associated with 5-fluorouracil-resistance in human gastric cancer cells

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Abstract

A comparative cDNA microarray analysis was carried out using human gastric cancer cells and their derivative cells made resistant to 5-fluorouracil. Three genes, SRP72, DNA primase, and caspase-6, were identified that were transiently induced by 5-fluorouracil and also overexpressed in 5-fluorouracil-resistant gastric cancer cells.

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Authors and Affiliations

  1. Division of Functional Genomics, In2Gen Company, 28, Yongon-dong, Chongno-gu, Seoul, 110-799, Korea

    Saeyoung Park, Mina Lee, Hosoon Lee & Doo-il Jeoung

  2. Institute of Life Sciences and Biotechnology and Plant Metabolism Research Center, Kyung Hee University, Suwon, 449-701, Korea

    Hae-Yeong Kim

  3. Laboratory of Radiation Effects, Korea Cancer Center Hospital, 215-4, Gongneung-Dong, Nowon-Gu, Seoul, 139-706, Korea

    Yun-Sil Lee

  4. LGCI Life Science R&D, 104-1 Moonji-Dong, Yuseong-Gu, Daejeon, 305-830, Korea

    Shinwu Jeong

Authors
  1. Saeyoung Park
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  2. Mina Lee
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  3. Hosoon Lee
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  4. Hae-Yeong Kim
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  5. Yun-Sil Lee
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  6. Shinwu Jeong
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  7. Doo-il Jeoung
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Park, S., Lee, M., Lee, H. et al. Identification of signature genes associated with 5-fluorouracil-resistance in human gastric cancer cells. Biotechnology Letters 24, 1651–1657 (2002). https://doi.org/10.1023/A:1020665820180

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  • DOI: https://doi.org/10.1023/A:1020665820180

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