Abstract
Inhibitors of the key enzyme of cholesterol biosynthesis beta-hydroxy-beta-methylglutaryl-coenzyme A reductase (statins) decrease cholesterol content in atherogenic low-density lipoproteins in patients with coronary heart disease and hypercholesterolemia, but inhibited biosynthesis of ubiquinone Q10 protecting low-density lipoproteins from free radical oxidation. Cerivastatin in a daily dose of 0.4 mg markedly increased the content of lipid peroxides in low-density lipoproteins. However, complex therapy with cerivastatin and antioxidant probucol (250 mg/day) was accompanied by a sharp decrease in the content of lipid peroxides in low-density lipoproteins in patients with coronary heart disease in vivo. These data indicate that antioxidant agents should be used in combination with inhibitors of beta-hydroxy-beta-methylglutaryl-coenzyme A reductase (hypolipidemic preparations) for the therapy of patients with coronary heart disease.
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Lankin, V.Z., Tikhaze, A.K., Konovalova, G.G. et al. Intensification of Free Radical Oxidation of Low-Density Lipoproteins in the Plasma of Patients with Ischemic Heart Disease Receiving beta-Hydroxy-beta-Methylglutaryl-Coenzyme A Reductase Inhibitor Cerivastatin and Inhibition of Low-Density Lipoprotein Peroxidation with Antioxidant Probucol. Bulletin of Experimental Biology and Medicine 134, 39–42 (2002). https://doi.org/10.1023/A:1020652504303
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DOI: https://doi.org/10.1023/A:1020652504303