Abstract
We have developed a two-step method for synthesis of 3-(hetarylthio)-1-propynyl(trimethyl)silanes from thiols in a phase-transfer catalysis system HCCCH2Br-solid K2CO3-18-crown-6-toluene followed by reaction with n-BuLi-Me3SiCl in ether or THF. We have observed that 3-[1,3-bis(trimethylsilyl)-2-propynyl]thioindole displays high cytotoxicity in HT-1080 and MG-22A tumor cell lines.
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Abele, R., Abele, E., Rubina, K. et al. Synthesis and Cytotoxicity of 3-(Hetarylthio)-1-propynyl(trimethyl)silanes. Chemistry of Heterocyclic Compounds 38, 867–872 (2002). https://doi.org/10.1023/A:1020650224525
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DOI: https://doi.org/10.1023/A:1020650224525