Abstract
Experiments used is combination with traditional preparations (omeprasole, de-nol, and solcoseril), Semax peptide (Met-Glu-His-Phe-Pro-Gly-Pro) possessing nootropic and neuroprotective activity significantly promoted ulcer healing in patients with refractory peptic ulcers. On day 14 of treatment ulcer healing was observed in 89.5% patients receiving intranasal Semax (1% solution, 2-4 drops 3 times a day for 10 days) vs. 30.8% in the control group. Clinical studies of antiulcer activity of Semax in different combinations with usual antiulcer drugs are needed.
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REFERENCES
I. P. Ashmarin, V. N. Nezavibat'ko, N. F. Myasoedov, et al., Zh. Vyssh. Nervn. Deyat., 47, 420–430 (1997).
I. P. Ashmarin, G. E. Samonina, N. Ya. Zheleznyak, and Z. V. Bakaeva, Dokl. Akad. Nauk SSSR, 368,No. 2, 709–710 (1999).
S. E. Zhuikova, E. A. Smirnova, Z. V. Bakaeva, et al., Byull. Eksp. Biol. Med., 130,No. 9, 300–302 (2000).
S. E. Zhuikova, V. I. Sergeev, G. E. Samonina, and N. F. Myasoedov, Ibid., 133,No. 6, 665–667 (2002).
I. V. Ivanov and V. V. Yasnetsov, Eksp. Klin. Farmakol., 63,No. 1, 41–44 (2000).
N. F. Myasoedov, V. I. Skvortsova, E. L. Nasonov, et al., Zh. Nevrol. Psikhiatr., 9,No. 5, 15–19 (1999).
G. S. Polunin, S. M. Nurieva, D. L. Bayandin, et al., Vestn. Oftal'mol., 116,No. 1, 15–18 (2000).
A. J. Kaplan, A. A. Kamensky, V. B. Koshelev, et al., Neurosci. Res. Commun., 16,No. 2, 105–112 (1995).
G. Samonina, L. Lyapina, G. Kopylova, et al., Pathophysiology, 7,No. 1, 69–73 (2000).
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Ivanikov, I.O., Brekhova, M.E., Samonina, G.E. et al. Therapy of Peptic Ulcer with Semax Peptide. Bulletin of Experimental Biology and Medicine 134, 73–74 (2002). https://doi.org/10.1023/A:1020621124776
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DOI: https://doi.org/10.1023/A:1020621124776