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Enhanced fibronectin-mediated cell adhesion of human osteoblast by fibroblast growth factor, FGF-2

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Abstract

Using specific recombinant human fibronectin peptide (hFNIII9-10) that contains the binding site for integrin, we found that the fibroblast growth factor, FGF-2, enhances fibronectin-mediated adhesion in human osteoblast-like MG63 cells. The mechanism of the synergistic adhesion was due to the activation of extracellular-regulated kinase (ERK)-type MAPK upon interaction of integrin to hFNIII9-10 and its downstream activation of signaling pathways.

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Authors and Affiliations

  1. Intellectual Biointerface Engineering Center, Seoul National University College of Dentistry, Seoul, 110-768, Korea

    Jun-Hyeog Jang, Young Ku, Chong-Pyoung Chung & Seong-Joo Heo

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  1. Jun-Hyeog Jang
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  2. Young Ku
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  3. Chong-Pyoung Chung
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  4. Seong-Joo Heo
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Jang, JH., Ku, Y., Chung, CP. et al. Enhanced fibronectin-mediated cell adhesion of human osteoblast by fibroblast growth factor, FGF-2. Biotechnology Letters 24, 1659–1663 (2002). https://doi.org/10.1023/A:1020617904251

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  • DOI: https://doi.org/10.1023/A:1020617904251

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