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Journal of Clinical Immunology

, Volume 19, Issue 6, pp 365–377 | Cite as

A Portrait of the Bcl-2 Protein Family: Life, Death, and the Whole Picture

  • Marc Pellegrini
  • Andreas Strasser
Article

Abstract

The Bcl-2 family of proteins are important regulators of cell death. They are comprised of two opposing factions, the proapoptotic versus the antiapoptotic members. Both are required for normal development and cellular homeostasis of the immune system and other tissues. However, in certain circumstances they may participate in the development of disease.

Bcl-2 family of proteins apoptosis cancer autoimmunity infection 

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Copyright information

© Plenum Publishing Corporation 1999

Authors and Affiliations

  1. 1.The Walter and Eliza Hall Institute of Medical ResearchMelbourneAustralia

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