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Benzathine Penicillin G and Procaine Penicillin G in Piglets: Comparison of Intramuscular and Subcutaneous Injection

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Abstract

The disposition of penicillin G in piglets is described after intramuscular or subcutaneous injection of depot preparations. The piglets were injected with 33 000 IU/kg or 100 000 IU/kg benzathine + procaine penicillin G intramuscularly or subcutaneously, or 100 000 IU/kg procaine penicillin G intramuscularly or subcutaneously. Intramuscular injection of benzathine + procaine penicillin resulted in higher maximum concentration in plasma (Cmax) than did subcutaneous injection. The mean residence time (MRT) of penicillin G was longer when the drugs were injected subcutaneously rather than intramuscularly. The plasma concentration versus time profiles of the subcutaneous injections of benzathine + procaine penicillin revealed secondary peaks, possibly reflecting a certain degree of inflammation at the injection site.

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Authors and Affiliations

  1. Department of Pharmacology, Microbiology and Food Hygiene, Norway

    B. Ranheim, V. Hormazabal, M. Yndestad & N.E. Søli

  2. Department of Reproduction and Forensic Medicine, The Norwegian School of Veterinary Science, PB, 8146 Dep., NO-0033, Oslo, Norway

    H. Ween & A.K. Egeli

Authors
  1. B. Ranheim
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  2. H. Ween
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  3. A.K. Egeli
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  4. V. Hormazabal
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  5. M. Yndestad
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  6. N.E. Søli
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Ranheim, B., Ween, H., Egeli, A. et al. Benzathine Penicillin G and Procaine Penicillin G in Piglets: Comparison of Intramuscular and Subcutaneous Injection. Vet Res Commun 26, 459–465 (2002). https://doi.org/10.1023/A:1020590408947

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  • DOI: https://doi.org/10.1023/A:1020590408947

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