Skip to main content
SpringerLink
Log in

Prostate-specific antigen, prostate volume and transition zone volume in Japanese patients with histologically proven benign prostatic hyperplasia

  • Published:
International Urology and Nephrology Aims and scope Submit manuscript

    We’re sorry, something doesn't seem to be working properly.

    Please try refreshing the page. If that doesn't work, please contact support so we can address the problem.

Abstract

The relationship among age, prostate-specific antigen (PSA) level andprostate volume in Japanese patients with lower urinary tract symptoms(LUTS) and histologically proven benign prostatic hyperplasia (BPH) wasexamined in order to assess the utility of PSA as a predictor of prostatevolume. Two hundred eighteen patients with LUTS were confirmed to haveBPH by histological examination for the reason of elevated PSA and/orabnormal digital rectal examination finding. Correlation among PSA,prostate volume and transition zone volume were analyzed in patientsclassified into age-stratified groups. Prostate volume increased with age.Mean serum PSA increased with age, and the correlation of PSA and prostatevolume was determined to be statistically significant in each cohort of age.A correlation coefficient ranged from 0.315 to 0.439. In patients with LUTSand clinical BPH, serum PSA increased with age and was related to prostatevolume. PSA might be useful for therapeutic decision making for patientswith symptomatic BPH.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Benson MC, Whang JS, Olsson CA et al. The use of prostate specific antigen density to enhance the predictive value of intermediate levels of serum prostate specific antigen. J Urol 1992; 147: 817.

    Google Scholar 

  2. Catalona WJ, Smith DS, Ratliff TL et al. Measurement of prostate-specific antigen in serum as a screening tests for prostate cancer. New Engl J Med 1991; 324: 1156.

    Google Scholar 

  3. Collins GN, Lee RJ, McKelvie GB et al. Relationship between prostate specific antigen, prostate volume and age in the benign prostate. Br J Urol 1993; 71: 445.

    Google Scholar 

  4. Di Silverio F, Sciarra A, D'Eramo G et al. Relationship among age, prostate-specific antigen, and prostate volume in men with lower urinary tract symptoms (LUTS) and in different groups of men with and without benign and malignant prostate diseases. Prostate 1998; 36: 1.

    Google Scholar 

  5. Djavan B, Zlotta AR, Byttebier G et al. Prostate specific antigen density of the transition zone for early detection of prostate cancer. J Urol 1998; 160: 411.

    Google Scholar 

  6. Hammerer PG, McNeal JE, Stamey TA. Correlation between serum prostate specific antigen levels and the volume of the individual glandular zones of the human prostate. J Urol 1995; 153: 111.

    Google Scholar 

  7. Hochberg DA, Armenakas NA, Fracchia JA. Relationship of prostate-specific antigen and prostate volume in patients with biopsy proven benign prostatic hyperplasia. Prostate 2000; 45: 315.

    Google Scholar 

  8. Kalish J, Cooner WH, Graham SD. Serum PSA adjusted for volume of transition zone (PSAT) is more accurate than PSA adjusted for total gland volume (PSAD) in detecting adenocarcinoma of the prostate. Urology 1994; 43: 601.

    Google Scholar 

  9. McConnell JD, Bruskewitz R, Walsh P et al. The effect of finasteride on the risk of acute urinary retention and the need for surgical treatment among men with benign prostatic hyperplasia. N Engl J Med 1998; 338: 557.

    Google Scholar 

  10. Oesterling JE. Prostate specific antigen: a critical assessment of the most useful tumor marker for adenocarcinoma of the prostate. J Urol 1991; 145: 907.

    Google Scholar 

  11. Partin AW, Oesterling JE. The clinical usefulness of prostate specific antigen: update 1994. J Urol 1994; 152: 1358.

    Google Scholar 

  12. Roehrborn CG, Boyle P, Gould AL, Waldstreicher J. Serum prostate-specific antigen as a predictor of prostate volume in men with benign prostatic hyperplasia. Urology 1999; 53: 581.

    Google Scholar 

  13. Roehrborn CG, McConnell JD, Lieber M et al. Serum prostate-specific antigen is a powerful predictor of acute urinary retention and need for surgery in men with clinical benign prostatic hyperplasia. Urology 1999; 53: 473.

    Google Scholar 

  14. Ruud Bosch JLH, Hop WCJ, Bangma CH et al. Prostate specific antigen in a community-based sample of men without prostate cancer: correlations with prostate volume, age, body mass index, and symptoms of prostatism. Prostate 1995; 27: 241.

    Google Scholar 

  15. Yasuhara K. Prostate-specific antigen density and velocity for detection of localized prostate cancer. Chiba Med J 1996; 72: 379.

    Google Scholar 

  16. Yatani R, Shiraishi T, Nakakuki K et al. Trends in frequency of latent prostate carcinoma in Japan from 1965–1979 to 1982–1986. J Natl Cancer Inst 1988; 80: 683.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Urology, Teikyo University School of Medicine, Ichihara Hopsital, Ichihara, Japan

    Y. Furuya, S. Ohta, N. Sato, T. Kotake & M. Masai

Authors
  1. Y. Furuya
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. S. Ohta
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. N. Sato
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. T. Kotake
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. M. Masai
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Furuya, Y., Ohta, S., Sato, N. et al. Prostate-specific antigen, prostate volume and transition zone volume in Japanese patients with histologically proven benign prostatic hyperplasia. Int Urol Nephrol 33, 645–648 (2001). https://doi.org/10.1023/A:1020539404686

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1023/A:1020539404686

Keywords

Search

Navigation