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Intracellular lipid binding proteins of the small intestine

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Abstract

The small intestine contains three distinct proteins belonging to the intracellular lipid binding protein family: the liver-type fatty acid binding protein (L-FABP), the intestinal fatty acid binding protein (I-FABP) and the ileal lipid binding protein (ilbp). The function of these proteins in the small intestine has remained enigmatic. Targeted gene disruption studies may shed insights into the physiological importance of these proteins. In the case of I-FABP, this approach has demonstrated that the complete elimination of this protein in murine intestine does not compromise dietary fat absorption in vivo but is associated with the development of insulin resistance.

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Authors and Affiliations

  1. Canadian Institutes of Health Research Group in Molecular and Cell Biology of Lipids and Department of Biochemistry, University of Alberta, 328 Heritage Medical Research Centre, Edmonton, AB, T6G 2S2, Canada

    Luis B. Agellon

  2. Novartis Institute for Biomedical Research, Summit, NJ, 07901, USA

    Matthew J. Toth

  3. Department of Medicine, University of Alberta, Edmonton, Canada

    Alan B.R. Thomson

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  1. Luis B. Agellon
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  2. Matthew J. Toth
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  3. Alan B.R. Thomson
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Agellon, L.B., Toth, M.J. & Thomson, A.B. Intracellular lipid binding proteins of the small intestine. Mol Cell Biochem 239, 79–82 (2002). https://doi.org/10.1023/A:1020520521025

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  • DOI: https://doi.org/10.1023/A:1020520521025

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