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Modified Coumarins. 4. Synthesis and Biological Properties of Cyclopentaneannelated Furocoumarins

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Chemistry of Natural Compounds Aims and scope

Abstract

Psoralen and allopsoralen analogs that contain an annelated cyclopentane were synthesized from 7-hydroxyand 9-hydroxy-1,2,3,4-tetrahydrocyclopenta[c]chromen-4-ones. 9-Phenyl-1,2,3,4-tetrahydrocyclopenta[c]furo[3,2-g]chromen-4-one exhibited low toxicity, acted as a CNS stimulant, and exhibited cardiotropic activity.

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Authors and Affiliations

  1. Institute of Bioorganic and Petroleum Chemistry, National Academy of Sciences of the Ukraine, 02094, Kiev, ul. Murmanskaya, 1

    M. M. Garazd

  2. Taras Shevchenko Kiev National University, 01033, the Ukraine, Kiev, ul. Vladimirskaya, 64

    Ya. L. Garazd, S. V. Shilin & V. P. Khilya

  3. Institute of Gerontology, Academy of Medical Sciences of the Ukraine, 03114, Kiev, ul. yshgorodskaya, 67

    T. N. Panteleimonova

Authors
  1. M. M. Garazd
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  2. Ya. L. Garazd
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  3. S. V. Shilin
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  4. T. N. Panteleimonova
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  5. V. P. Khilya
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Garazd, M.M., Garazd, Y.L., Shilin, S.V. et al. Modified Coumarins. 4. Synthesis and Biological Properties of Cyclopentaneannelated Furocoumarins. Chemistry of Natural Compounds 38, 230–242 (2002). https://doi.org/10.1023/A:1020423826071

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