Journal of Assisted Reproduction and Genetics

, Volume 15, Issue 10, pp 583–586 | Cite as

Low Plasma Levels of hCG After 10,000-IU hCG Injection Do Not Reduce the Number or Maturation of Oocytes Recovered in Patients Undergoing Assisted Reproduction

  • Saad Al-Hassan
  • Simon Fishel
  • Steven Fleming
  • Simon Thornton


Purpose: Our purpose was to determine whether there is a correlation between human chorionic gonadotropin (hCG) blood levels and oocyte maturation.

Methods: Three samples of blood were obtained at different times from hCG administration as follows: 12 hr, 36 hr, during oocyte recovery, and at 84 hr, when the patient comes for embryo transfer.

Results: A total of 5036 oocytes was retrieved from 404 patients prospectively recruited between April 1996 and March 1997. The percentage of metaphase-II oocytes at different blood levels ranged from 84 to 88%. The general trend does not show any significant increase in percentage of metaphase-II oocytes in association with an increasing serum hCG concentration.

Conclusions: The results of this study suggest that at 12, 36, and 84 hr after hCG administration, levels as low as 50, 45, and 9 IU/L of hCG, respectively, are equally potent as higher levels at initiating maximal oocyte maturity.

human chorionic gonadotropin maturation metaphase-II oocytes 


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Copyright information

© Plenum Publishing Corporation 1998

Authors and Affiliations

  • Saad Al-Hassan
    • 1
    • 2
  • Simon Fishel
    • 1
  • Steven Fleming
    • 1
  • Simon Thornton
    • 1
  1. 1.Department of Obstetrics & GynaecologyNottingham University Research and Treatment Unit in Reproduction (NURTURE)NottinghamUK
  2. 2.Department of Obstetrics & GynaecologyKing Faisal Specialist Hospital & Research CentreRiyadhSaudi Arabia

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