Skip to main content
SpringerLink
Log in

Age-Related Peculiarities of the Effect of alpha-Adrenoreceptor Blockade on Cardiac Function in Rats

  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

Blockade of alpha1-adrenoreceptors with prazosin produces bradycardia. The degree of this bradycardia in rats depends on age. In adult (20-week-old) rats bradycardia is pronounced, in 3-week-old rats it is insignificant, and in 1-week-old rats bradycardia does not develop. Prazosin moderates bradycardia induced by vagal stimulation in rats of different age.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

REFERENCES

  1. T. L. Zefirov and N. V. Svyatova, Byull. Eksp. Biol. Med., 126,No. 12, 612–614 (1998).

    Google Scholar 

  2. V. E. Benediktsdottir, G. V. Sculadottir, S. Gudbjarnason, Eur. J. Pharmacol., 289,No. 3, 419–427 (1995).

    Google Scholar 

  3. M. N. Levy, T. Yang, and D. W. Wallieck, J. Cardiovasc. Electrophysiol., 4,No. 2, 189–193 (1993).

    Google Scholar 

  4. Q. Y. Liu, E. Karpinski, and P. K. Pang, FEBS Lett., 338,No. 2, 234–238 (1994).

    Google Scholar 

  5. M. Nagashima, Y. Hattori, Y. Akaishi, et al., Am. J. Physiol., 271,No. 4, Pt. 2, 1423–1432 (1996).

    Google Scholar 

  6. R. B. Robinson, Cardiovasc. Res., 31, 68–86 (1996).

    Google Scholar 

  7. H. Saito, H. Togashi, and M. Yoshioka, Am. J. Hypertens., 9,No. 11, 160S-169S (1996).

    Google Scholar 

  8. K. Saito, T. Suetsugu, Y. Oku, et al, Br. J. Pharmacol., 111,No. 2, 465–468 (1994).

    Google Scholar 

  9. G. S. Yu, M. Z. Chen, and Q. D. Han, Chung Kuo Yao LI Hsueh Pao, 16,No. 5, 452–454 (1995).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Normal Physiology, Kazan' State Medical University, Russia

    N. I. Ziyatdinova, A. L. Zefirov & T. L. Zefirov

  2. Department of Anatomy, Physiology, and Human Health Protection, Kazan State Pedagogical University, Russia

    N. I. Ziyatdinova, A. L. Zefirov & T. L. Zefirov

Authors
  1. N. I. Ziyatdinova
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. A. L. Zefirov
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. T. L. Zefirov
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Ziyatdinova, N.I., Zefirov, A.L. & Zefirov, T.L. Age-Related Peculiarities of the Effect of alpha-Adrenoreceptor Blockade on Cardiac Function in Rats. Bulletin of Experimental Biology and Medicine 133, 532–534 (2002). https://doi.org/10.1023/A:1020257103336

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1023/A:1020257103336

Search

Navigation