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Effect of Monoamine Oxidase A Knockout on Resistance to Long-Term Exposure to Ethanol

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Abstract

It was shown that transgenic Tg8 mice with monoamine oxidase A (MAO A) gene knockout demonstrate higher resistance to acute ethanol exposure compared to wild type C3H mice. This difference was observed at the early age (28-30 days). Long-term ethanol treatment changed the resistance to hypnotic, but not hypothermic action of this agent. Seven-day exposure increased the resistance to ethanol-induced narcotic sleep in Tg8 and C3H mice. After 30-day ethanol treatment the duration of narcotic sleep sharply decreased in C3H mice and increased in Tg8 mice, which attested to their decreased tolerance to ethanol.

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Authors and Affiliations

  1. Laboratory of Phenogenetics of Behavior, Institute of Cytology and Genetics, Siberian Department of the Russian Academy of Sciences, Novosibirsk

    E. A. Ivanova & N. K. Popova

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  1. E. A. Ivanova
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  2. N. K. Popova
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Ivanova, E.A., Popova, N.K. Effect of Monoamine Oxidase A Knockout on Resistance to Long-Term Exposure to Ethanol. Bulletin of Experimental Biology and Medicine 133, 603–605 (2002). https://doi.org/10.1023/A:1020254430169

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  • DOI: https://doi.org/10.1023/A:1020254430169

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