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Radiation-Induced Crosslinking of Thymine with Cysteamine: Cysteamine Attachment to the Methyl Group of Thymine

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Abstract

5-S-Cysteaminemethyluracil (the product of cysteamine attachment to the methyl group of thymine) was isolated from irradiated solutions containing thymine and cysteamine and identified. This compound was formed in the reaction of thiyl radicals with 5-methyleneuracil-5-yl radicals formed by H-atom abstraction from the methyl group of thymine. This product was not formed in the presence of oxygen.

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REFERENCES

  1. Smith, K.C., Photochemistry and Photobiology of Nucleic Acids, Wang, S.Y., Ed., New York: Academic, 1976, vol. 1, p. 186.

    Google Scholar 

  2. Shetlar, M.D. and Hom, K., Photochem. Photobiol., 1987, vol. 45, no. 6, p. 703.

    Google Scholar 

  3. Smith, K.C., Biochem. Biophys. Res. Commun., 1969, vol. 34, p. 354.

    Google Scholar 

  4. Grachev, S.A., Kropachev, E.V., and Litvyakova, G.I., Izv. Akad. Nauk SSSR, Ser. Khim., 1984, no. 6, p. 1270.

  5. Grachev, S.A., Kropachev, E.V., and Litvyakova, G.I., Izv. Akad. Nauk SSSR, Ser. Khim., 1983, no. 8, p. 1762.

  6. Bagiyan, G.A., Grachev, S.A., Koroleva, I.K., and Soroka, N.V., Zh. Obshch. Khim., 1976, vol. 46, no. 1, p.365.

    Google Scholar 

  7. Grand, A. and Cadet, J., Acta Crystallogr., Sect. B: Struct. Crystallogr. Cryst. Chem., 1978, vol. 34, p. 1524.

    Google Scholar 

  8. Cline, R.E., Fink, R.M., and Fink, K., J. Am. Chem. Soc., 1959, vol. 81, no. 10, p. 2521.

    Google Scholar 

  9. Field, L., Owen, T.C., Crenshow, R.R., and Bryon, A.W., J. Am. Chem. Soc., 1961, vol. 83, no. 12, p. 4414.

    Google Scholar 

  10. Ellman, G.L., Arch. Biochem. Biophys., 1959, vol. 82, p.70.

    Google Scholar 

  11. Von Sonntag, C. and Schuchmann, H.-P., Int. J. Radiat. Biol., 1986, vol. 49, no. 1, p. 1.

    Google Scholar 

  12. Pikaev, A.K. and Kabakchi, S.A., Reaktsionnaya sposobnost' pervichnykh produktov radioliza vody (Reactivity of Primary Products of Water Radiolysis, Handbook), Moscow: Energoizdat, 1982.

    Google Scholar 

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Authors and Affiliations

  1. Konstantinov Institute of Nuclear Physics, Russian Academy of Sciences, Gatchina, 188350, Russia

    E. V. Kropachev & G. I. Litvyakova

Authors
  1. S. A. Grachev
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  2. E. V. Kropachev
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  3. G. I. Litvyakova
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Grachev, S.A., Kropachev, E.V. & Litvyakova, G.I. Radiation-Induced Crosslinking of Thymine with Cysteamine: Cysteamine Attachment to the Methyl Group of Thymine. High Energy Chemistry 36, 290–293 (2002). https://doi.org/10.1023/A:1020234314373

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