Skip to main content
SpringerLink
Log in

Effect of Megestrol Caproate on the Reproductive Function of Laboratory Animals

  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

In vivo experiments on rats and rabbits showed that megestrol caproate, a 17-alpha-hydroxyprogesterone derivative exhibits 10-fold higher gestagenic activity compared to progesterone and possesses no androgenic, anabolic, and estrogenic activities.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

REFERENCES

  1. T. I. Ivanenko, E. V. Pokrovskaya, V. I. Fedotov, et al., Eksp. Klin. Farmakol., No. 2, 36–39 (1994).

  2. Ya. M. Kabak, Endocrinology Practicum [in Russian], Moscow (1990).

  3. V. V. Korkhov, Contraceptives: Manual for Physicians [in Russian], St. Petersburg (2000).

  4. V. V. Korkhov, Medical Aspects of Using Contraceptives [in Russian], St. Petersburg (1996).

  5. V. V. Korkhov, Farmakol. Toksikol., No. 1, 77–80 (1990).

  6. E. A. Lesik, New Synthetic and Natural Drugs Stimulating and Inhibiting Reproduction in Experiment, Abstract of Cand Biol. Sci. Dissertation, St. Petersburg (1998).

  7. G. A. Merkulov, A Course of Pathological Methods [in Russian], Leningrad (1991), P. 13.

  8. G. V. Nikitina, Farmakol. Toksikol., No. 2, 43–46 (1991).

  9. V. M. Sidel'nikova, E. M. Demidova, Yu. F. Borisova, et al., Akush. Ginek., No. 9, 37–40 (1990).

  10. O. M. Connely, J. P. Lydon, F. Mayo, and B. W. O'Malley, J. Soc. Gynecol. Investig., 7,Suppl. 1, 25–32 (2000).

    Google Scholar 

  11. R. J. Dorfman and A. S. Dorfman, Endocrinology, 55, 65 (1954).

    Google Scholar 

  12. R. L. Kleiman, Hormonal Contraception, London (1990).

  13. M. K. McPhail, J. Physiol., 84, 145–147 (1934).

    Google Scholar 

  14. A. Negro-Vilar, J. Soc. Gynecol. Investig., 7,Suppl. 1, 53–54 (2000).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Laboratory of Pharmacology, D. O. Ott Institute of Obstetrics and Gynecology, Russian Academy of Medical Sciences, St. Petersburg

    O. L. Pirzada

Authors
  1. O. L. Pirzada
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to O. L. Pirzada.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Pirzada, O.L. Effect of Megestrol Caproate on the Reproductive Function of Laboratory Animals. Bulletin of Experimental Biology and Medicine 133, 574–576 (2002). https://doi.org/10.1023/A:1020233925626

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1023/A:1020233925626

Search

Navigation