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Key Role of Succinate Dehydrogenase in Insulin-Induced Inactivation of Protein Tyrosine Phosphatases

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Abstract

We studied the role of mitochondria in insulin-induced inactivation of protein tyrosine phosphatases in the liver. The mitochondrial respiratory chain is an insulin-sensitive source of H2O2that acts as a physiological inhibitor of protein tyrosine phosphatases. Succinate dehydrogenase plays a key role in insulin-stimulated generation of H2O2and inactivation of liver protein tyrosine phosphatases.

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Authors and Affiliations

  1. Department of General Pathology and Pathophysiology, Russian Medical Academy of Postgraduate Education, Russian Ministry of Health, Moscow

    I. A. Pomytkin & O. E. Kolesova

Authors
  1. I. A. Pomytkin
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  2. O. E. Kolesova
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Correspondence to I. A. Pomytkin.

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Pomytkin, I.A., Kolesova, O.E. Key Role of Succinate Dehydrogenase in Insulin-Induced Inactivation of Protein Tyrosine Phosphatases. Bulletin of Experimental Biology and Medicine 133, 568–570 (2002). https://doi.org/10.1023/A:1020229724717

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  • DOI: https://doi.org/10.1023/A:1020229724717

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