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In Vitro Effect of Short Peptides on Expression of Interleukin-2 Gene in Splenocytes

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Abstract

Synthetic peptides Vilon (Lys-Glu), Epithalon (Ala-Glu-Asp-Gly), and Cortagen (Ala-Glu-Asp-Pro) in vitro activated interleukin-2 mRNA synthesis in splenocytes from CBA mice in the absence of specific inductors. The intensity of interleukin-2 mRNA synthesis in splenocytes depended on the type, concentration, and duration of treatment with the peptides. Vilon and Epithalon were most potent, while Cortagen produced a less pronounced effect on interleukin-2 mRNA synthesis.

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Authors and Affiliations

  1. Department of General Pathology and Pathophysiology, Institute of Experimental Medicine, Russian Academy of Medical Sciences, Russia

    T. B. Kazakova, S. V. Barabanova, V. Kh. Khavinson, M. S. Glushikhina, E. P. Parkhomenko, V. V. Malinin & E. A. Korneva

  2. St. Petersburg Institute of Bioregulation and Gerontology, Northwestern Division of the Russian Academy of Medical Sciences, St. Petersburg

    T. B. Kazakova, S. V. Barabanova, V. Kh. Khavinson, M. S. Glushikhina, E. P. Parkhomenko, V. V. Malinin & E. A. Korneva

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  1. T. B. Kazakova
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  2. S. V. Barabanova
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  3. V. Kh. Khavinson
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  4. M. S. Glushikhina
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  5. E. P. Parkhomenko
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  6. V. V. Malinin
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  7. E. A. Korneva
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Kazakova, T.B., Barabanova, S.V., Khavinson, V.K. et al. In Vitro Effect of Short Peptides on Expression of Interleukin-2 Gene in Splenocytes. Bulletin of Experimental Biology and Medicine 133, 614–616 (2002). https://doi.org/10.1023/A:1020210615148

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  • DOI: https://doi.org/10.1023/A:1020210615148

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