Skip to main content
SpringerLink
Log in

Reversal of Sodium Arsenite Inhibition of Rat Liver Microsomal Ca2+ Pumping ATPase by Vitamin C

  • Published:
Bioscience Reports

Abstract

Sodium arsenite (NaAsO2), at 10% of its median lethal dose, was administered to rats with and without vitamin C pretreatment. Liver microsomal fraction was isolated and the activity of Ca2+-ATPase was assayed. Sodium arsenite was found to inhibit the activity of the liver microsomal Ca2+-ATPase to 50% to that of control rats. The specific activity of the enzyme in rats administered sodium arsenite with vitamin C pretreatment was not significantly different from that of control rats.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

REFERENCES

  1. Webb, J. L. (1966) Enzyme and Metabolic Inhibitors. Academic Press, New York 3:595-793.

    Google Scholar 

  2. Ramos, O. et al. (1995) Environ. Health Perspect. 103:Suppl 1:85-88.

    Google Scholar 

  3. Huang, R. N., Ho, I. C., Yin, L. H., and Lee, T. C. (1995) Environ. Mol. Mutag. 25:188-196.

    Google Scholar 

  4. Brown, J. L. and Kitchen, H. T. (1996) Cancer 98(2):227-231.

    Google Scholar 

  5. Adenuga, G. A., Bababunmi, E. A., and Hendrickse, R. G. (1972) Toxicol. 71:1-6.

    Google Scholar 

  6. Lowrey, K., Glende, E. A. Jr., and Recknagel, R. O. (1981) Biochem. Pharmacol. 30:135.

    Google Scholar 

  7. Thastrup, O., Orobak, B. K., Hemley, M. N., and Dawson, A. P. (1990) Proc. Nat. Acad. Sci. U.S.A. 87:2466-2470.

    Google Scholar 

  8. Loewenstein, W. R. (1979) Biochem. Biophys. Acta 560:1-59.

    Google Scholar 

  9. Lim-Sylianco, C. N. (1993) Molecular Nutrition. The Academy, Metro Manila, Philippines.

    Google Scholar 

  10. Lowry, O. H., Rosebrough, N. J., Farr, A. L., and Randal, N. J. (1951) J. Biol. Chem. 193:265-275.

    Google Scholar 

  11. Fiske, G. H. and Subbarow, Y. (1925) J. Biol. Chem. 66:375-400.

    Google Scholar 

  12. Carafoli, E. (1987) Ann. Rev. Biochem. 56:395-433.

    Google Scholar 

  13. Odunuga, O. O. and Adenuga, G. A. (1997) Biosci. Rep. 17(6):543-546.

    Google Scholar 

  14. Balestrero, F., Morelli, A., Damonte, G., Yoci, A., and Orunesu, M. (1990) Ital. J. Biochem. 39(4):250-257.

    Google Scholar 

  15. Halliwell, B. and Gutteridge, J. M. C. (1990) Arch. Biochem. Biophys. 286:1-8.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Laboratory for Biomembrane Research, Department of Biochemistry, College of Medicine, University of Ibadan, Ibadan, Nigeria

    Odutayo O. Odunuga, Gbolahan W. Okunade & Olufunso O. Olorunsogo

Authors
  1. Odutayo O. Odunuga
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Gbolahan W. Okunade
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Olufunso O. Olorunsogo
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Odunuga, O.O., Okunade, G.W. & Olorunsogo, O.O. Reversal of Sodium Arsenite Inhibition of Rat Liver Microsomal Ca2+ Pumping ATPase by Vitamin C. Biosci Rep 19, 11–15 (1999). https://doi.org/10.1023/A:1020189806066

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1023/A:1020189806066

Search

Navigation