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A Novel Phosphorylated Lipid Counteracts Activation of the Renal Plasma Membrane (Ca2+ + Mg2+)ATPase by Endogenous Phosphatidylinositol-4-Phosphate

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Bioscience Reports

Abstract

The plasma membrane (Ca2+ + Mg2+)ATPase is activated by acidic phospholipids in reconstituted systems. In this report it is shown that reversible phosphorylation of endogenous phosphatidylinositol regulates the renal plasma membrane (Ca2+ + Mg2+)ATPase, and that a novel phosphorylated lipid that can be isolated from the same membrane strongly counteracts the stimulatory effect of phosphatidylinositol-4-phosphate.

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Authors and Affiliations

  1. Departmento de Bioquímica Médica, Universidade Federal do Rio de Janeiro, Rio de Janeiro, 21941-590, Brazil

    Adilson Guilherme, Cledson Reis-Silva, Jorge H. Moraes-Albuquerque & Adalberto Vieyra

  2. Instituto de Biofisica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, 21941-590, Brazil

    Mecia M. Oliveira

Authors
  1. Adilson Guilherme
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  2. Cledson Reis-Silva
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  3. Jorge H. Moraes-Albuquerque
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  4. Mecia M. Oliveira
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  5. Adalberto Vieyra
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Guilherme, A., Reis-Silva, C., Moraes-Albuquerque, J.H. et al. A Novel Phosphorylated Lipid Counteracts Activation of the Renal Plasma Membrane (Ca2+ + Mg2+)ATPase by Endogenous Phosphatidylinositol-4-Phosphate. Biosci Rep 18, 79–89 (1998). https://doi.org/10.1023/A:1020184210183

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