Abstract
Ina retrospective study validated by a standardized clinical and radiologicalexamination, the bone regeneration in 90 patients with cystic mandibulardefectswas examined. In 50 patients bony defect reconstructions with humandemineralised bone matrix (HDBM) were carried out, while in a comparable groupof 40 patients the hollow pockets were left to regenerate bone spontaneously.The bone regeneration after the implantation of human demineralised bone matrix(HDBM) was subjected to a comparative validation. Osteoinductive proteinspresent in HDBM (bone morphogenetic proteins) can diffuse into the implant seatand induce new bone formation (osteoinduction). A markedly faster and morethorough bone regeneration was demonstrated after the surgical therapy ofcysticmandibular lesions with HDBM than without. HDBM also proved to be exceptionallybiocompatible.
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Kuhls, R., Werner-Rustner, M., Küchler, I. et al. Human demineralised bone matrix as a bone substitute for reconstruction of cystic defects of the lower jaw. Cell Tissue Banking 2, 143–153 (2001). https://doi.org/10.1023/A:1020173119669
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DOI: https://doi.org/10.1023/A:1020173119669