Skip to main content
SpringerLink
Log in

Iron-Induced Oxidative Stress in Erythrocyte Membranes of Non-Insulin-Dependent Diabetic Nigerians

  • Published:
Bioscience Reports

Abstract

The presence of higher level of endogenous free radical reaction products in the erythrocyte ghost membrane (EGM) of Non-insulin-dependent diabetes mellitus (NIDDM) subjects compared with that of normal healthy controls has been demonstrated. The EGMs of NIDDM subjects were also shown to be more susceptible to exogenously generated oxidative stress than those of normal healthy individuals. The decreased level of reactive thiol groups in the EGM of NIDDM individuals supported this observation. We propose that the presence of significant levels of non-heme iron in the EGM of NIDDM subjects is an indication of the potential for iron-catalysed production of hydroxy and other toxic radicals which could cause continuous oxidative stress and tissue damage. Oxygen free radicals could therefore be responsible for most of the erythrocyte abnormalities associated with non-insulin-dependent diabetes and could indeed be intimately involved in the mechanism of tissue damage in diabetic complications.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

REFERENCES

  1. WHO expert committee (1985) WHO technical report, Ser. N 727, WHO, Geneva.

    Google Scholar 

  2. Oli, J. M. (1983) J. R. Coll. Physicians Lond. 17:224-227.

    Google Scholar 

  3. Zimmet, P. (1982) Diabetologia 22:399-411.

    Google Scholar 

  4. Gabbay, K. H. (1970) N. Engl. J. Med. 288:831-836.

    Google Scholar 

  5. Brownlee, M., Vlassara, H., and Cerami, A. (1984) Ann. Intern. Med. 101:527-537.

    Google Scholar 

  6. Thornalley, P. J. and Stern, A. (1984) Carbohydrates Res. I 134:191-201.

    Google Scholar 

  7. Arai, K., Lizuka, S., Tada, Y., Oikawa, K., and Taniguchi, N. (1987) Biochem. Biophys. Acta 924:292-296.

    Google Scholar 

  8. Deb, S., Choudary, P. R., Mukhorjee, S. N., and Chatterjee, S. N. (1981) Metabolism 30:572-577.

    Google Scholar 

  9. Karpen, C. W., Cataland, S., O'Dorisio, T. M., and Panganamala, R. (1984) Diabetes 33:239-243.

    Google Scholar 

  10. Illing, E. K., Gray, C. H., and Lawrence, R. D. (1951) Biochem. J. 48:637-640.

    Google Scholar 

  11. Sato, Y., Hotta, N., Sakamoto, N., Matosuoka, S., Ohishi, N., and Yagi, K. (1979) Biochem. Med. 21:104-107.

    Google Scholar 

  12. Lowry, O. H., Rosebrough, N. J., Farr, A. D., and Randall, A. J. (1951) J. Biol. Chem. 193:265-275.

    Google Scholar 

  13. Rice-Evans, C., Omorphos, S. C., and Baysal, E. (1986) Biochem. J. 237:265-269.

    Google Scholar 

  14. Ceriotti, F. and Ceriotti, G. (1980) Clin. Chem. 26:327-331.

    Google Scholar 

  15. Ellman, G. L. (1959) Arch. Biochem. Biophys. 74:443-450.

    Google Scholar 

  16. Heikkila, R. E., Winston, B., Cohen, G., and Barden, H. (1976) Biochem. Pharmacol. 25:1085-1092.

    Google Scholar 

  17. Granksvist, K., Marklund, S., and Taljedahl, I. B. (1979) FEBS Lett. 105:15-18.

    Google Scholar 

  18. Jones, R. L. and Peterson, C. M. (1981) Am. J. Med. 70:339-352.

    Google Scholar 

  19. Trivelli, L. A., Ranney, H. N., and Lai, M. T. (1971) N. Engl. J. Med. 284:353-357.

    Google Scholar 

  20. Gabbay, K. H., Hasty, K., Breslow, J. L., Ellison, R. C., Bunn, H. F., and Gallop, P. M. (1976) J. Clin. Endocrinol. Metab. 44:859-865.

    Google Scholar 

  21. Schmid-Schonben, H. and Volger, E. (1976) Diabetes 25:(Suppl. 2): 897-902.

    Google Scholar 

  22. Wall, R. K., Jaffe, S., Kumar, D., and Klara, V. K. (1988) Diabetes 37:104-111.

    Google Scholar 

  23. Kamada, T. and Otsuji, S. (1983) Diabetes 32:585-591.

    Google Scholar 

  24. Murakami, K., Kondo, T., Ohtsuka, Y., Furiwara, Y., Shimada, M., and Kawakami, Y. (1989) Metabolism 38:753-758.

    Google Scholar 

  25. Sato, M., Imazumi, K., Bessho, T., and Shiga, T. (1989) Diabetologia 27:517-521.

    Google Scholar 

  26. Mazzanti, L., Rabini, R. A., Testa, I., and Bertoli, E. (1989) Eur. J. Clin. Invest. 19:84-89.

    Google Scholar 

  27. Gorda, C., Rossi, J. P. F. C., (Edola, N. V. and Gagiardino, J. J.) (1986) IRCS Med. Sci. 14:479.

    Google Scholar 

  28. Wantier, J. C. et al. (1981) N. Engl. J. Med. 305:237-241.

    Google Scholar 

  29. Pescarmona, G. P., Bosia, A., and Ghigo, D. (1982) In: Advances in Red Cell Biology, Weatheral, D. J., Fiorelli, G., and Gorini, S. (eds), New York, Raven, pp. 391-397.

    Google Scholar 

  30. Gambhir, K. K., Archer, J. A., and Carter, L. (1977) Clin. Chem. 23:1590-1595.

    Google Scholar 

  31. Rice-Evans, C., Omorphos, S. C., Baysal, E. (1986) In: Free Radicals, Cell Damage and Disease. Rice-Evans, C. (ed.), Richelieu Press, London, pp. 147-166.

    Google Scholar 

  32. Rice-Evans, C., Omorphos, S. C., Baysal, E. and Aquino, M. D. (1985) In: Approaches to the Therapy of Sickle Cell Anaemia: Les Edition INSERM, Beuzard, Y., Charache, S., and Galactros, F. (ed.), Paris, pp. 345-428.

  33. Jain, S. K. (1984) J. Biol. Chem. 259:3391-3394.

    Google Scholar 

  34. Wall, R. K., Jafe, S., Kumar, D., Soregenete, N., and Kalra, V. K. (1987) J. Cell. Physiol. 113:25-36.

    Google Scholar 

  35. Graf, E. et al. (1982) Biochem. 21:4511-4516.

    Google Scholar 

  36. Hebbel, R. P., Shalev, O., Foker, W., and Rank, B. H. (1986) Biochem. Biophys. Acta 862:8-46.

    Google Scholar 

  37. O'Brien, P. J. (1969) Can. J. Biochem. 47:485-492.

    Google Scholar 

  38. Engstrom, K. G., Grankvist, K., and Taljedal, I. B. (1990) Diabetologia 33:127-130.

    Google Scholar 

  39. Cutler, P. (1989) Diabetes 38:1207-1210.

    Google Scholar 

  40. Van der Kraaij, A. M. M., Biemond, P., Van Eijk, H. G., Swaak, A. J. G., and Foster, J. F. (1989). in: Free Radicals, Metal Was and Biopolymers, Beaumont, P. C., Deeble, D. J., and Rice-Evans, C. (eds), Richelieu Press, London, pp. 217-232.

    Google Scholar 

  41. Cerami, A. (1986) Trends Biochem. Sci. 11:311-314.

    Google Scholar 

  42. Esterbauer, H., Jurgens, J., Quahnberger, O., and Koller, E. (1987) J. Lipid Res. 28:495-509.

    Google Scholar 

  43. Hunt, J. V., Smith, C. C. T., and Wolf, S. D. (1990) Diabetes 39:1420-1424.

    Google Scholar 

  44. Erikson, U. J. and Borg, L. A. H. (1991) Diabetologia 34:325-331.

    Google Scholar 

  45. Hunt, J. V., Dean, R. T., and Wolff, S. P. (1988) Biochem. J. 256:205-212.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Laboratory for Biomembrane Research, Department of Biochemistry, College of Medicine, University of Ibadan, Ibadan, Nigeria

    Gbolahan W. Okunade, Odutayo O. Odunuga & Olufunso O. Olorunsogo

Authors
  1. Gbolahan W. Okunade
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Odutayo O. Odunuga
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Olufunso O. Olorunsogo
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Okunade, G.W., Odunuga, O.O. & Olorunsogo, O.O. Iron-Induced Oxidative Stress in Erythrocyte Membranes of Non-Insulin-Dependent Diabetic Nigerians. Biosci Rep 19, 1–9 (1999). https://doi.org/10.1023/A:1020113121995

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1023/A:1020113121995

Search

Navigation