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Progesterone Regulation of Reproductive Function Through Functionally Distinct Progesterone Receptor Isoforms

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References

  1. Conneely OM, Kettelberger DM, Tsai MI, Schrader WT O'Malley BW. The chicken progesterone receptor A and B isoforms are products of an alternate translation initiation event. J Biol Chem 1989;264:14062-14064.

    Google Scholar 

  2. Kastner P, Krust A, Turcotte B, Suopp U, Tora L, Gronemeyer H, Chambon P. Two distinct estrogen-regulated promoters generate transcripts encoding the two functionally different human progesterone receptor forms A and B. EMBO J 1990;9:1603-1614.

    Google Scholar 

  3. Shyamala G, Schneider W, Schott D. Developmental regulation of marine mammary progesterone receptor gene expression. Endocrinology 1990;126:2882-2889.

    Google Scholar 

  4. Duffy DM, Wells TR, Haluska GJ, Stouffer RL. The ratio of progesterone receptor isoforms changes in the monkey corpus luteum during the luteal phase of the menstrual cycle. Biol Reprod 1997;57:693-699.

    Google Scholar 

  5. Brandon DD, Bethea CL, Strawn FY, Navy MJ, Burry KA, Harrington MS, Erickson TE, Warner C, Keenan El, Clinton GM. Progesterone receptor messenger ribonucleic acid and protein are over-expressed in human uterine leiomyomas. Am J Obstet Gynecol 1993;169:78-85.

    Google Scholar 

  6. Graham JD, Yeates C, Balleine RL, Harvey SS, Milliken JS, Bilous AM, Clarke CL. Progesterone receptor A and B protein expression in human breast cancer. J Steroid Biochem Mol Biol 1996;56:93-98.

    Google Scholar 

  7. Tsai MI, O'Malley BW. Molecular mechanisms of action of steroid/thyroid receptor super family members. Annu Rev Biochem 1994;63:451-486.

    Google Scholar 

  8. Giangrande PH, McDonnell DP. The A and B isoforms of the human progesterone receptor: two functionally different transcription factors encoded by a single gene (in process citation). Recent Prog Horm Res 1999;54:291-313.

    Google Scholar 

  9. Guiochon-Mantel A, Loosfelt H, Lescop P, Mechanisms of nuclear localization of the progesterone receptor: evidence for interaction between monomers. Cell 1989;57:1147-1154.

    Google Scholar 

  10. McKenna NJ, Xu I, Nawaz Z, Tsai SY, Tsai MI, O'Malley BW. Nuclear receptor coactivators: multiple enzymes, multiple complexes, multiple functions. J Steroid Biochem Mol Biol 1999;69:312.

    Google Scholar 

  11. Rowan BG, O'Malley BW. Progesterone receptor coactivators. Steroids 2000;65:545-549.

    Google Scholar 

  12. Rowan BG, Garrison N, Weigel NL, O'Malley BW. 8-Bromocyclic AMP induces phosphorylation of two sites in SRG-1 that facilitate ligand-independent activation of the chicken progesterone receptor and are critical for functional cooperation between SRC-1 and CREB binding protein. Mol Cell Biol 2000;20:8720-8730.

    Google Scholar 

  13. Sartorius CA, Melville MY, Hovland AR, Tung L, Takimoto GS, Horwitz KB. A third transactivation function (AF3) of human progesterone receptors located in the unique N-terminal segment of the B-isoform. Mol Endocrinol 1994a;8:1347-1360.

    Google Scholar 

  14. Wen DX, Xu YF, Mais DE, Goldman ME, McDonnell DP. The A and B isoforms of the human progesterone receptor operate through distinct signaling pathways within target cells. Mol Cell Biol 1994;14:8356-8364.

    Google Scholar 

  15. Giangrande PH, Kimbrel FA, Edwards DP, McDonnell DP. The opposing transcriptional activities of the two isoforms of the human progesterone receptor are due to differential cofactor binding. Mol Cell Biol 2000;20:3102-3115.

    Google Scholar 

  16. Tom L, Gronemeyer H, Turcotte B, Gaut, MP, Chambon P. The N-terminal region of the chicken progesterone receptor specifies target gene activation. Nature 1988;333:185-188.

    Google Scholar 

  17. Meyer ME, Quirin-Stricker C, Lerouge T, Bocquel MT, Gronemeyer H. A limiting factor mediates the differential activation of promoters by the human progesterone receptor isoforms. J Biol Chem 1992;267:10882-10887.

    Google Scholar 

  18. Vegeto F, Shahbaz MM, Wen DX, Goldman ME, O'Malley BW, McDonnell DP. Human progesterone receptor A form is a cell-and promoter-specific repressor of human progesterone receptor B function. Mol Endocrinol 1993;7:1244-1255.

    Google Scholar 

  19. Hovland AR, Powell RL, Takimoto GS, Tung L, Horwitz KB. An N-terminal inhibitory function, IF, suppresses transcription by the A-isoform but not the B-isoform of human progesterone receptors. J Biol Chem 1998;273:5455-5460.

    Google Scholar 

  20. McDonnell DP, Shahbaz MM, Vegem F, Goldman ME. The human progesterone receptor A-form functions as a transcriptional modulator of mineralocorticoid receptor transcriptional activity. J Steroid Biochem Mol Biol 1994;48:425-432.

    Google Scholar 

  21. Sartorius CA, Groshong SD, Miller LA. New T47D breast cancer cell lines for the independent study of progesterone B-and A-receptors: only antiprogestin-occupied B-receptors are switched to transcriptional agonists by cAMP. Cancer Res 1994b;54:3868-3877.

    Google Scholar 

  22. Musgrove FA, Hamilton JA, Lee CS, Sweeney KJ, Watts CK, Sutherland RL. Growth factor, steroid, and steroid antagonist regulation of cyclin gene expression associated with changes in T47D human breast cancer cell cycle progression. Mol Cell Biol 1993;13:3577-3587.

    Google Scholar 

  23. Beck CA, Weigel NL, Moyer ML, Nordeen SK, Edwards DP. The progesterone antagonist RU486 acquires agonist activity upon stimulation of cAMP signaling pathways. Proc Natl Acad Sci USA 1993;90:4441-4445.

    Google Scholar 

  24. Tetel MJ, Giangrande PH, Leonhardt SA, McDonnell DP, Edwards DP. Hormone-dependent interaction between the amino-and carboxyl-terminal domains of progesterone receptor in vitro and in vivo. Mol Endocrinol 1999;13:910-924.

    Google Scholar 

  25. Lydon JP, DeMayo FJ, Funk CR, Mani SK, Hughes AR, Montgomery CA Jr, Shyamala G, Conneely OM, O'Malley BW. Mice lacking progesterone receptor exhibit pleiotropic reproductive abnormalities. Genes Dev 1995;9:2266-2278.

    Google Scholar 

  26. Chappell PF, Lydon JP, Conneely OM, O'Malley BW Levine JE. Endocrine defects in mice carrying a null mutation for the progesterone receptor gene. Endocrinology 1997;138:4147-4152.

    Google Scholar 

  27. Chappell PF, Schneider JS, Kim P, Xu M, Lydon JP, O'Malley BW, Levine JE. Absence of gonadotropin surges and gonadotropin releasing hormone self-priming in ovariectomized (OVX), estrogen (E2)-treated, progesterone receptor knockout (PRKO) mice. Endocrinology 1999;140:3653-3658.

    Google Scholar 

  28. Mani SK, Allen JM, Lydon JP, Mulac-Jericevic B, Blaustein JD, DeMayo FJ, Conneely O, O'Malley BW. Dopamine requires the unoccupied progesterone receptor to induce sexual neurobehavior in mice. Mol Endocrinol 1996;10:1728-1737.

    Google Scholar 

  29. Tibbetts TA, DeMayo F, Rich S, Conneely OM, O'Malley BW. Progesterone receptors in the thymus are required for thymic involution during pregnancy and for normal fertility. Proc Natl Acad Sci USA 1999;96:12021-12026.

    Google Scholar 

  30. Vazquez F, Rodriguez-Manzaneque JC, Lydon JP, Edwards DP, O'Malley BW, Iruela-Arispe ML. Progesterone regulates proliferation of endothelial cells. J Biol Chem 1999;274:2185-2192.

    Google Scholar 

  31. Conneely OM, Maxwell BL, Taft DO, Schrader WT, O'Malley BW. The A and B forms of the chicken progesterone receptor arise by alternate initiation of translation of a unique mRNA. Biochem Biophys Res Commun 1987;149:493-501.

    Google Scholar 

  32. Giangrande PH, Pollio G, McDonnell DP. Mapping and characterization of the functional domains responsible for the differential activity of the A and B isoforms of the human progesterone receptor. J Biol Chem 1997;272:32889-32900.

    Google Scholar 

  33. Mulac-Jericevic B, Mullinax RA, DeMayo FJ, Lydon JP, Conneely OM. Subgroup of reproductive functions of progesterone mediated by progesterone receptor-B isoform. Science 2000;289:1751-1754.

    Google Scholar 

  34. Loutradis D, Bletsa R, Aravantinos L, Kallianidis K, Michalas S, Psychoyos A. Preovulatory effects of the progesterone antagonist mifepristone (RU486) in mice. Hum Reprod 1991;6:1238-1240.

    Google Scholar 

  35. Park-Sarge OK, Mayo KE. Regulation of the progesterone receptor gene by gonadotropins and cyclic adenosine 3',5'-monophosphate in rat granulosa cells. Endocrinology 1994;134:709-718.

    Google Scholar 

  36. Natraj U, Richards JS. Hormonal regulation, localization, and functional activity of the progesterone receptor in granulosa cells of rat preovulatory follicles. Endocrinology 1993;133:761-769.

    Google Scholar 

  37. Park OK, Mayo KE. Transient expression of progesterone receptor messenger RNA in ovarian granulosa cells after the preovulatory luteinizing hormone surge. Mol Endocrinol 1991;5:967-978.

    Google Scholar 

  38. Robker RL, Russell DL, Espey LL, Lydon JP, O'Malley BW, Richards JS. Progesterone-regulated genes in the ovulation process: ADAMTS-1 and cathepsin L proteases. Proc Natl Acad Sci USA 2000;97:4689-4694.

    Google Scholar 

  39. Espey LLaL, H. In: Knobil EaN, J. D., ed. The Physiology of Reproduction. New York: Raven, 1994:725-780.

    Google Scholar 

  40. Dinchuk JF, Car BD, Focht RJ, Johnston JJ, Jaffee BD, Covington MB, Contel NR, Eng VM, Collins RJ, Czemiak PM, Gorry SA, Trzaskos JM. Renal abnormalities and an altered inflammatory response in mice lacking cyclooxygenase II. Nature 1995;378:406-409.

    Google Scholar 

  41. Morham SG, Langenbach R, Loftin CD, Tiano HF, Vouloumanos N, Jennette JC, Mahler JF, Kluckman KD, Ledford A, Lee CA, Smithies O. Prostaglandin synthase 2 gene disruption causes severe renal pathology in the mouse. Cell 1995;83:473-482.

    Google Scholar 

  42. Shindo T, Kurihara H, Kuno K, Yokoyama H, Wada T, Kurihara Y, Imai T, Wang Y, Ogata M, Nishimatsu H, Moriyama N, Oh-hashi Y, Morita H, Ishikawa T, Nagai R, Yazaki Y, Matsushima K. ADAMTS-1: a metalloproteinase-disintegrin essential for normal growth, fertility, and organ morphology and function [see comments]. J Clin Invest 2000;105:1345-1352.

    Google Scholar 

  43. Ledford BF, Rankin JC, Markwald RR, Baggett B. Biochemical and morphological changes following artificially stimulated decidualization in the mouse uterus. Biol Reprod 1976;15:529-535.

    Google Scholar 

  44. Zhu LJ, Cullinan-Bove K, Polihronis M, Bagchi MK, Bagchi IC. Calcitonin is a progesterone-regulated marker that forecasts the receptive state of endometrium during implantation. Endocrinology 1998;139:3923-3934.

    Google Scholar 

  45. Das SK, Chakraborty J, Paria BC, Wang XN, Plowman G, Dey SK. Amphiregulin is an implantation-specific and progesterone-regulated gene in the mouse uterus. Mol Endocrinol 1995;9:691-705.

    Google Scholar 

  46. Paria BC, Das N, Das SK, Zhao X, Dileepan KN, Dey SK. Histidine decarboxylase gene in the mouse uterus is regulated by progesterone and correlates with uterine differentiation for blastocyst implantation. Endocrinology 1998;139:3958-3966.

    Google Scholar 

  47. McMaster MT, Teng CT, Dey SK, Andrews GK. Lactoferrin in the mouse uterus: analyses of the preimplantation period and regulation by ovarian steroids. Mol Endocrinol 1992;6:101-111.

    Google Scholar 

  48. Clarke CL, Sutherland RL. Progestin regulation of cellular proliferation. Endocr Rev 1990;11:266-301.

    Google Scholar 

  49. Kraus WL, Weis KE, Katzenellenbogen BS. Inhibitory cross-talk between steroid hormone receptors: differential targeting of estrogen receptor in the repression of its transcriptional activity by agonist-and antagonist-occupied progestin receptors. Mol Cell Biol 1995;15:1847-1857.

    Google Scholar 

  50. Lydon JP, Sivaraman L, Conneely OM. A reappraisal of progesterone signaling in the mammary gland. J Mammary Gland Biol Neoplasia 2000;5:325-338.

    Google Scholar 

  51. Seagraves TN, Lydon JP, Hovey RC, Vonderhaar BK, Rosen JM. C/EBPbeta (CCAAT/enhancer binding protein) controls cell fate determination during mammary gland development. Mol Endocrinol 2000;14:359-368.

    Google Scholar 

  52. Sivaraman L, Hilsenbeck SG, Zhong L, Gay J, Conneely OM, Medina D, O'Malley BW. Early exposure of the rat mammary gland to estrogen and progesterone blocks co-localization of estrogen receptor expression and proliferation. J Endocrinol 2001;171:75-83.

    Google Scholar 

  53. Brisken C, Park S, Vass T, Lydon JP, O'Malley BW, Weinberg RA. A paracrine role for the epithelial progesterone receptor in mammary gland development. Proc Natl Acad Sci USA 1998;95:5076-5081.

    Google Scholar 

  54. Clarke RE, Howell A, Patten CS, Anderson F. Dissociation between steroid receptor expression and cell proliferation in the human breast. Cancer Res 1997;57:4987-4991.

    Google Scholar 

  55. Brisken C, Heineman A, Chavarria T, Elenbaas B, Tan J, Dey SK, McMahon JA, McMahon AP, Weinberg RA. Essential function of Wnt-4 in mammary gland development downstream of progesterone signaling. Genes Dev 2000;14:650-654.

    Google Scholar 

  56. Fantl V, Edwards PA, Steel JH, Vonderhaar BK, Dickson C. Impaired mammary gland development in Ctyl-1(-/-) mice during pregnancy and lactation is epithelial cell autonomous. Dev Biol 1999;212:1-11.

    Google Scholar 

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  1. Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, 77030

    Orla M. Conneely & Biserka M. Jericevic

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Correspondence to Orla M. Conneely.

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Conneely, O.M., Jericevic, B.M. Progesterone Regulation of Reproductive Function Through Functionally Distinct Progesterone Receptor Isoforms. Rev Endocr Metab Disord 3, 201–209 (2002). https://doi.org/10.1023/A:1020020308980

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