Skip to main content
SpringerLink
Log in

Growth-inhibiting Effects of Intralesional Docetaxel and Paclitaxel on an Experimental Model of Malignant Neuroectodermal Tumor

  • Published:
Journal of Neuro-Oncology Aims and scope Submit manuscript

Abstract

Taxoids are effective agents against a wide variety of tumors, but their effectiveness on neuroectodermal tumors is not well-known. For this reason we have carried out an experimental study on the effect of intratumoral administration of docetaxel (DC) and paclitaxel (PC) on tumor growth, using a murine model of malignant neuroectodermal tumor. The results showed a delay in tumor growth in animals treated with PC compared with controls (dose of 5 mg/kg, three times per week every other day, forming a cycle; three cycles were completed with a break of a week between each cycle). The total dose administered to each animal was 45 mg/kg. When DC was administered, the results showed distinct tumor growth inhibition and tumor regression in 80% of animals (intratumoral administration at a dose of 5 mg/kg, three times per week every other day forming a cycle; three cycles were completed with a break of a week between each cycle). The total dose administered to each animal was 20 mg/kg. These results suggest the utility of taxoids, mainly DC, by intralesional administration, on malignant tumors of the nervous system.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Wani MC, Taylor HL, Wall ME, Coggon P, McPhail AT: Plant antitumor agents IV: the isolation and structure of taxol, a novel antileukemic and antitumor agent from Taxus brevifolia. J Am Chem Soc 93: 2325–2327, 1971

    Google Scholar 

  2. Schiff PB, Fant J, Horowitz SB: Promotion of microtubule assembly in vitro by taxol. Nature 22: 665–667, 1979

    Google Scholar 

  3. Denis JN, Greene AE, Guénard D, Guéritte-Voegelein F, Guénard D, Mangatal L, Potier P: A highly efficient, practical approach to natural taxol. J Am Chem Soc 10: 5917–5919, 1988

    Google Scholar 

  4. Mangatal L, Adeline MT, Guénard D Guéritte-Voegelein F, Mangatal L, Potier P: Application of the vicinal oxyamination reaction with asymmetric induction to the hemisynthetisis of taxol and analogues. Tetrahedron 45: 177–190, 1989

    Google Scholar 

  5. Gelmon K: The taxoids: paclitaxel and docetaxel. Lancet 344: 1267–1272, 1994

    Google Scholar 

  6. Spencer CM, Faulds D: Paclitaxel: a reviewof its pharmacodynamic and pharmacokinetic properties and therapeutic potential in the treatment of cancer. Drugs 48: 794–847, 1994

    Google Scholar 

  7. Fulton B, Spencer CM: Docetaxel: a review of its pharmacodynamic and pharmacokinetic properties and therapeutic efficacy in the management of metastatic breast cancer. Drugs 51: 1075–1092, 1996

    Google Scholar 

  8. Guéritte-Voegelein F, Guénard D, Lavelle F, Le-Goff MT, Mangatal L, Potier P: Relationships between the structure of taxol analogues and their antimitotic activity. J Med Chem 34: 992–998, 1991

    Google Scholar 

  9. Riou JF, Petitgenet O, Combeauc C: Cellular uptake and efflux of docetaxel (Taxotere) and paclitaxel (Taxol) in P388 cell line. Proc Am Assoc Cancer Res 35: 385, 1994 (Abstract)

    Google Scholar 

  10. Kelland LR, Abel G: Comparative in vitro cytotoxicity of Taxol and Taxotere against cisplantin-sensitive and resistant human ovarian carcinoma cell lines. Cancer Chemother Pharmacol 30: 444–450, 1992

    Google Scholar 

  11. Braakhuis BJM, Hill BT, Dietel M, Kelland LR, Aapro MS, Zoli W, Levieveld P: In vitro antiproliferative activity of docetaxel (Taxotere), paclitaxel (Taxol) and cisplatin against human tumors and normal bone marrow cells. Anticancer Res 14: 205–208, 1994

    Google Scholar 

  12. Hanauske AR, Degen D, Hilsenbeck SG, Bissery MC, Von-Hoff DD: Effects of Taxotere and Taxol on in vitro colony formation of freshly explanted human tumor cells. Anticancer Drugs 3: 121–124, 1992

    Google Scholar 

  13. Cahan MA, Walter KA, Colvin OM, Brem H: The cytotoxicity of taxol in vitro against human and rat malignant brain tumors. Cancer Chemother Pharmacol 33: 441–444, 1994

    Google Scholar 

  14. Bissery MC, Guènard D, Guèritte-Voegelein F, Lavelle F: Experimental antitumor activity of Taxotere (RP 56976, NSC 628503), a taxol analogue. Cancer Res 51: 4845–4852, 1991

    Google Scholar 

  15. Dykes DJ, Bissery MC, Harrison SD, Waud WR: Response of human tumor xenografts in athymic nude mice to docetaxel (RP 56976, Taxotere). Invest New Drugs 13: 1–11, 1995

    Google Scholar 

  16. Boven E, Venema-Gaberscek E, Erkelens CAM, Bissery MC, Pinedo HM: Antitumor activity of Taxotere (RP 56976, NSC 628503), a new taxol analogue, in experimental ovarian cancer. Ann Oncol 4: 321–324, 1993

    Google Scholar 

  17. Nicoletti MI, Lucchini V, D'Incalci M, Giavazzi R: Comparison of paclitaxel and docetaxel activity on human ovarian carcinoma xenografts. Eur J Cancer 30A: 691–696, 1994

    Google Scholar 

  18. Lavelle F, Bissery MC, Combeau C, Riou JF, Vrignaud P, Andre S: Preclinical evaluation of docetaxel (Taxotere). Semin Oncol 22(Suppl 4): 3–16, 1995

    Google Scholar 

  19. Rose WC: Taxol: a reviewof its preclinical in vivo antitumor activity. Anti Cancer Drugs 3: 311–321, 1992

    Google Scholar 

  20. Eisenhauer EA, Vermorken JB: The taxoids: comparative clinical pharmacology and therapeutic potential. Drugs 55: 5–30, 1998

    Google Scholar 

  21. Prados MD, Schold SC, Spence AM, Berger MS, McAllister LD, Metha MP, Gilbert MR, Fulton D, Kuhn J, Lamborn K, Rector DJ, Chang SM: Phase II study of paclitaxel in patients with recurrent malignant glioma. J Clin Oncol 14: 2316–2321, 1996

    Google Scholar 

  22. Chamberlain MC, Kormanik PA: Salvage chemotherapy with paclitaxel for recurrent primary brain tumors. J Clin Oncol 13: 2066–2071, 1995

    Google Scholar 

  23. Chamberlain MC, Kormanik PA: Salvage chemotherapy with paclitaxel for recurrent oligodendrogliomas. J Clin Oncol 15: 3427–3432, 1997

    Google Scholar 

  24. Forsyth P, Cairncross G, Stewart D, Goodyear M, Wainman N, Eisenhauer E: Phase II trial of docetaxel in patients with recurrent malignant glioma: a study of the National Cancer Institute of Canada Clinical Trials Group. Invest New Drugs 14: 203–206, 1996

    Google Scholar 

  25. Blaney SM, Seibel NL, O'Brien M, Reaman GH, Berg SL, Adamson PC, Poplack DG, Krailo MD, Mosher R, Balis FM: Phase I trial of docetaxel administered as a 1 h infusion in children with refractory solid tumors: a collaborative pediatric branch, National Cancer Institute and Children's Cancer Group Trial. J Clin Oncol 15: 1538–1543, 1997

    Google Scholar 

  26. Vaquero J, Oya S, Coca S, Zurita M: Experimental induction of primitive neuroectodermal tumors in rats: a reapraisement of the ENU-model of neurocarcinogenesis. Acta Neurochir (Wien) 131: 294–301, 1994

    Google Scholar 

  27. Houchens DP: Therapy of human tumors in athymic (nude) mice. In: Gustav Fischer (ed.) Proceeding of the Symposium on the Use of Athymic Nude Mice in Cancer Research. pp 266–280, New York, 1978

  28. Tomita T: Interstitial chemotherapy for brain tumors: review. J Neuro-Oncol 10: 57–74, 1991

    Google Scholar 

  29. Terzis AJ, Thorsen F, Heese O, Visted T, Bjerkvig R, Dahl O, Arnold H, Gundersen G: Proliferation, migration and invasion of human glioma cells exposed to paclitaxel (Taxol) in vitro. Br J Cancer 75: 1744–1752, 1997

    Google Scholar 

  30. Riccardi A, Servidei T, Tornesello A, Puggioni P, Mastrangelo S, Rumi C, Riccardi R: Cytotoxicity of paclitaxel and docetaxel in human neuroblastoma cell lines. Eur J Cancer 31A: 494–499, 1995

    Google Scholar 

  31. Walter KA, Cahan MA, Gur A, Tyler B, Hilton J, Colvin OM, Burger PC, Domb A, Brem H: Interstitial taxol delivered from a biodegradable polymer implant against experimental malignant glioma. Cancer Res 54: 2207–2212, 1994

    Google Scholar 

  32. Mc Closkey DE, Kaufmann SH, Prestigiacomo LJ, Davidson NE: Paclitaxel induces programmed cell death in MDA-MB-468 human breast cancer cells. Clin Cancer Res 2: 847–854, 1996

    Google Scholar 

  33. Scatena CD, Stewart ZA, Mays D, Tang LJ, Keefer CJ, Leach SD, Pietenpol JA: Mitotic phosphorylation of Bcl-2 during normal cell cycle progression and Taxol induced growth arrest. J Biol Chem 273: 30777–30784, 1998

    Google Scholar 

  34. Blagosklonny MV, Schulte T, Nguyen P, Trepel J, Neckers LM: Taxol induced apoptosis and phosphorylation of bcl-2 protein involves c-Raf-1 signal transduction pathway. Cancer Res 56: 1851–1854, 1996

    Google Scholar 

  35. Milross CG, Mason KA, Hunter NR, Chung WR, Peters LJ, Milas L: Relationship of mitotic arrest and apoptosis to antitumor effect of paclitaxel. J Natl Cancer Inst 88: 1308–1314, 1996

    Google Scholar 

  36. Haldar S, Chintapalli J, Croce CM: Taxol induced bcl-2 phosphorylation and death of prostate cancer cells. Cancer Res 56: 1851–1854, 1996

    Google Scholar 

  37. Belotti D, Vergani V, Drudis T, Borsotti P, Pitelli MR, Viale G, Giavazzi R, Taraboletti G: The microtubule affecting drug paclitaxel has antiangiogenic activity. Clin Cancer Res 2: 1843–1849, 1996

    Google Scholar 

  38. Schimming R, Mason KA, Hunter N, Weil M, Kishi K, Milas L: Lack of correlation between mitotic arrest or apoptosis and antitumor effect of docetaxel. Cancer Chemother Pharmacol 43: 165–172, 1999

    Google Scholar 

  39. Manthey CL, Qureshi N, Stutz PL, Vogel SN: Lipopolysaccharide antagonists block taxol induced signaling in murine macrophages. J Exp Med 178: 695–702, 1993

    Google Scholar 

  40. Grunberg E, Eckert K, Maurer HR: Docetaxel treatment of HT-29 colon carcinoma cells reinforces the adhesion and immunocytotoxicity of peripheral blood lymphocytes in vitro. Int J Oncol 12: 957–963, 1998

    Google Scholar 

  41. Moos PJ, Muskardin DT, Fitzpatrick FA: Effect of taxol and taxotere on gene expression in macrophages: induction of the prostaglandin H synthase-2 isoenzyme. J Immunol 162: 467–473, 1999

    Google Scholar 

  42. Tishler RB, Geard CR, Hall EJ, Schiff PB: Taxol sensitizes human astrocytoma cells to radiation. Cancer Res 52: 3495–3499, 1992

    Google Scholar 

  43. Choy H, Rodriguez FF, Koester S, Hilsenbeck S, Von-Hoff D: Investigation of taxol as a potential radiation sensitizer. Cancer 71: 3774–3778, 1993

    Google Scholar 

  44. Mason KA, Hunter NR, Milas M, Abbruzzese JL, Milas L: Docetaxel enhances tumor radioresponse in vivo. Clin Cancer Res 3(12 Pt 1): 2431–2438, 1997

    Google Scholar 

  45. Wehbe T, Glantz M, Choy H, Glantz L, Cortez S, Akerley W III, Mills P, Cole B: Histologic evidence of a radiosensitizing effect of Taxol in patients with astrocytomas. J Neuro-Oncol 39: 245–251, 1998

    Google Scholar 

  46. Koukourakis MI, Giatromanolaki A, Schiza S, Kakolyris S, Georgoulias V: Concurrent twice a week docetaxel and radiotherapy: a dose escalation trial with immunological toxicity evaluation. Int J Radiant Oncol Biol Phys 43: 107–114, 1999

    Google Scholar 

  47. Glantz MJ, Chamberlain MC, Chang SM, Prados MD, Cole BF: The role of paclitaxel in the treatment of primary and metastatic brain tumors. Semin Radiant Oncol 9(2 Suppl 1): 27–33, 1999

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Laboratory of Experimental Neuro-Oncology, Neuroscience Research Unit of the Mapfre-Medicine Foundation, Puerta de Hierro Clinic, Autonomous University, Madrid, Spain

    C. Morales, M. Zurita & J. Vaquero

Authors
  1. C. Morales
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. M. Zurita
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. J. Vaquero
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Morales, C., Zurita, M. & Vaquero, J. Growth-inhibiting Effects of Intralesional Docetaxel and Paclitaxel on an Experimental Model of Malignant Neuroectodermal Tumor. J Neurooncol 59, 207–212 (2002). https://doi.org/10.1023/A:1019979813640

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1023/A:1019979813640

Search

Navigation