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Delayed Changes in Regional Brain Energy Metabolism following Cerebral Concussion in Rats

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Abstract

Traumatic brain injury (TBI) results in an acute altered metabolic profile of brain tissue which resolves within hours of initial insult and yet some of the functional deficits and cellular perturbations persist for days. It is hypothesized that a delayed change in energy status does occur and is a factor in the neural tissue's ability to survive and regain function. Regional metabolic profile and glucose consumption were determined at either 1 or 3 days following two different intensities of parasagittal fluid-percussion (F-P). A significant decrease in both 1CMRgluc and levels of ATP and P-creatine was evident in the hemisphere ipsilateral to the trauma at 1 day after the insult. The effect was greater in the cortical than the subcortical regions and was more pronounced at the higher trauma intensity. Normalization of glucose consumption and energy levels was essentially complete by 3 days. It would appear that the delayed metabolic changes at 1 day postinsult cannot be explained by a secondary ischemia since the changes in the metabolite profile do not elicit an increase in the consumption of glucose. These changes in energy metabolites may account for and contribute to the chronic neurological deficits following TBI.

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Authors
  1. Marek Buczek
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  2. Jamie Alvarez
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  3. Jaffar Azhar
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  4. Yinong Zhou
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  5. W. David Lust
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  6. Warren R. Selman
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  7. Robert A. Ratcheson
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Buczek, M., Alvarez, J., Azhar, J. et al. Delayed Changes in Regional Brain Energy Metabolism following Cerebral Concussion in Rats. Metab Brain Dis 17, 153–167 (2002). https://doi.org/10.1023/A:1019973921217

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