Skip to main content
SpringerLink
Log in

In-vitro forming of calcium phosphate layer on sol–gel hydroxyapatite-coated metal substrates

  • Published:
Journal of Materials Science: Materials in Medicine Aims and scope Submit manuscript

Abstract

In-vitro deposition of calcium phosphate layer (CPL) on metallic substrate requires special surface preparation in order to provide an interfacial bond. In this work 316 stainless steel surface is modified through deposition of a thin film (∼0.5 μm) of sol–gel hydroxyapatite (SG-HA). This well-bonded film acts as an intermediary and nucleation surface of the CPL film. The SG-HA films were annealed at 375 °C (samples coded 375-ACS) and 400 °C (400-ACS) to achieve different crystallinity of the films, and thus to affect and study the CPL nucleation process. The CPL growth was investigated in terms of deposition kinetics and microstructural development. A deposition rate of dense CPL of about 0.43 μm/day was achieved on the crystallized film of 400-ACS, and 0.22 μm/day of porous CPL on amorphous 375-ACS. A compositional variation of Ca/P ratio across the CPL film thickness (400-ACS) was observed. Lower Ca/P ratio of 1.2 was detected near the substrate-CPL interface and about 1.5 near the solution-CPL interface. Infrared analysis showed the CPL to be of apatitic calcium-deficient structure. Kinetic model explaining the advancement of the CPL upon the in-vitro immersion is proposed.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. L. L. Hench, J. Am. Ceram. Soc. 74 (1991) 1487-1510.

    Google Scholar 

  2. M. Jarcho, Clin. Orthop. 157 (1981) 259-78.

    Google Scholar 

  3. R. Z. Legeros, Adv. Dent. Res. 2 (1988) 164-168.

    Google Scholar 

  4. C. Ohtsuki, T. Kokubo and T. Yamamuru, J. Non-Cryst. Solids 143 (1992) 84-92.

    Google Scholar 

  5. P. Ducheyne, S. Radin and K. Ishikawa, in “Bone-Bonding Biomaterials”, edited by P. Duchenye, T. Kokubo and C. A. van Blitterswijk (Reed Healthcare Communications, Leiderdrop, 1992) pp. 213-18.

    Google Scholar 

  6. H. B. Wen, J. R. De Wijn, F. Z. Cui and K. De Groot, J. Biomed. Mater. Res. 41 (1998) 227-36.

    Google Scholar 

  7. S. Lin and A. A. Campbell, US patent #5 958 430 (1999).

  8. D. M. Liu, H. M. Chou and J. D. Wu, J. Mater. Sci. Mater. Med. 5 (1994) 147-153.

    Google Scholar 

  9. K. De Groot, R. G. T. Greesink, C. P. A. T. Klein and P. Serekian, J. Biomed. Mater. Res. 21 (1987) 1375-1381.

    Google Scholar 

  10. P. Ducheyne, W. Van Raemdonck, J. C. Heughebaert and M. Heughebaert, Biomaterials 11 (1990) 244.

    Google Scholar 

  11. S. Ban and S. Maruno, Jpn. J. App. Phys., part 2, Letters, 32[10B] (1993) 1577-80.

    Google Scholar 

  12. C. M. Cotell, App. Surf. Sci. 69 (1993) 140-48.

    Google Scholar 

  13. L. Torrisi and G. Foti, App. Phys. Letters 62 (1993) 237-39.

    Google Scholar 

  14. C. S. Chai, B. Ben-Nissan, S. Pyke and L. Evans, Mater. Manuf. Processes 10 (1995) 205-216.

    Google Scholar 

  15. C. M. Lopatin, V. Pizziconi, T. L. Alford and T. Laursen, Thin Solid Films 326 (1998) 227-232.

    Google Scholar 

  16. W. Weng and J. L. Baptista, J. Mater. Sci. Mater. Med. 9 (1998) 159-163.

    Google Scholar 

  17. D. M. Liu, T. Troczynski and W. J. Tseng, Biomaterials (in press, 2001).

  18. H. B. Wen, J. G. C. Wolke, J. R. De Wijn, Q. Lin, F. Z. Cui and K. De Groot, ibid. 18 (1997) 1471-78.

    Google Scholar 

  19. A. A. Campbell, G. E. Fryxell, J. C. Linehan and G. L. Graff, J. Biomed. Mater. Res. 32 (1996) 111-118.

    Google Scholar 

  20. D. M. Liu, Q. Yang and T. Troczynski, Biomaterials (in press, 2001).

  21. P. Li, C. Ohtsuki, T. Kokubo, K. Nakanishi, N. Soga and K. De Groot, J. Biomed. Mater. Res. 28 (1994) 7-15.

    Google Scholar 

  22. Y. Abe, T. Kokubo and T. Yamamuru, Materials in Medicine 1 (1990) 233-238.

    Google Scholar 

  23. S. R. Radin and P. Ducheyne, J. Biomed. Mater. Res. 27 (1993) 35-45.

    Google Scholar 

  24. H. P. Boehm, Disc. Faraday Soc. 52 (1971) 264-275.

    Google Scholar 

  25. K. E. Healy and P. Ducheyne, Biomaterials 13 (1992) 553-61.

    Google Scholar 

  26. S. Mann, B. R. Heywood, S. Rajam and V. J. Wale, in “Mechanism and Phylogeny of Mineralization in Biological Systems”, edited by S. Suga and H. Nakahara (Springer-Verlag, Tokyo, 1991) pp. 47-55.

    Google Scholar 

  27. J. W. Mullin, “Crystallization”, 2nd edn. (Butterworths, London, 1972) p. 189.

    Google Scholar 

  28. C. Combes, M. Freche, C. Rey and B. Biscans, Materials in Medicine 10 (1999) 231-237.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Metals and Materials Engineering, University of British Columbia, Vancouver, British Columbia, Canada, V6T 1Z4

    D.-M. Liu, Q. Yang & T. Troczynski

Authors
  1. D.-M. Liu
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Q. Yang
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. T. Troczynski
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Liu, DM., Yang, Q. & Troczynski, T. In-vitro forming of calcium phosphate layer on sol–gel hydroxyapatite-coated metal substrates. Journal of Materials Science: Materials in Medicine 13, 965–971 (2002). https://doi.org/10.1023/A:1019864713955

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1023/A:1019864713955

Keywords

Search

Navigation