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A New Method for Evaluation of Safety of Antiarrhythmic Drugs

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Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

A new method for preclinical evaluation of safety of antiarrhythmic drugs is proposed. During chronic stress, class I antiarrhythmic preparations increased mortality of test animals. By contrast, class II-IV antiarrhythmic agents and antioxidants produced no significant effect on mortality of experimental mice. These data agree with published results of multicenter studies.

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REFERENCES

  1. J. Alpert and G. Fransis, Handbook of Coronary Care, Moscow, (1994).

  2. M. Woodley and A. Whelan, in: Therapeutic Manual of Washington University [Russian Translation], Moscow (1995), pp. 186–235.

  3. M. S. Kushakovskii, Cardiac Arrhythmias [in Russian], St. Petersburg (1998).

  4. F. Z. Meerson, Pathogenesis and Prevention of Stress and Ischemic Damage to the Heart [in Russian], Moscow (1984).

  5. I. Ya. Moiseeva and Ya. V. Kostin, Vestn. Aritmol., 15, 173 (2000).

    Google Scholar 

  6. T. Buckingham, A. Volgman, and E. Wimer, Pacing Clin. Electrophysiol., 14, 1437–1439 (1994).

    Google Scholar 

  7. J. Cairns, S. Connolly, R. Roberts, et al., Lancet, 349, 675–682 (1997).

    Google Scholar 

  8. D. S. Echt, P. R. Liebson, L. B. Mitchel, et al., N. Engl. J. Med., 324, 781–788 (1991).

    Google Scholar 

  9. The cardiac arrhythmia suppression trial II investigators: Effect of the Antiarrhythmic Agent Moricizine on Survival after Miocardial Infarction, Ibid., 327, 227–233 (1992).

  10. C. D. Furberg, B. M. Psaly, and J. V. Meyer, Circulation, 92, 326–331 (1995).

    Google Scholar 

  11. C. D. Furberg, M. Pahor, and B. M. Psaly, Eur. Heart J., 17, 1142–1147 (1996).

    Google Scholar 

  12. C. H. Hennekens, J. E. Buring, J. F. Manson, et al., N. Engl. J. Med., 334, 1145–1149 (1996).

    Google Scholar 

  13. D. Julian, A. Camm, G. Frangin, et al., Lancet, 349, 667–674 (1997).

    Google Scholar 

  14. P. A. Poole-Wilson, Eur. Heart J., 17, 1131–1133 (1996).

    Google Scholar 

  15. B. M. Psaty, R. R. Heckbet, T. D. Koepsell, et al., JAMA, 224, 620–625 (1995).

    Google Scholar 

  16. N. G. Stephens, A. Parson, P. M. Schofield, et al., Lancet, 347, 781–786 (1996).

    Google Scholar 

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Authors and Affiliations

  1. Department of Biology, Mordvinian State University, Russia

    V. P. Balashov, L. A. Balykova, E. N. Shuvalova, T. I. Shevorakova & V. N. Poderov

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  1. V. P. Balashov
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  2. L. A. Balykova
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  3. E. N. Shuvalova
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  4. T. I. Shevorakova
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  5. V. N. Poderov
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Correspondence to V. P. Balashov.

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Balashov, V.P., Balykova, L.A., Shuvalova, E.N. et al. A New Method for Evaluation of Safety of Antiarrhythmic Drugs. Bulletin of Experimental Biology and Medicine 133, 518–520 (2002). https://doi.org/10.1023/A:1019842611550

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  • DOI: https://doi.org/10.1023/A:1019842611550

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