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Doxorubicin Modulates Biological Effects of ATP in Bone Marrow Cells In Vitro

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Abstract

ATP activity in mouse bone marrow cells was studied in in vitro experiments. ATP in physiological and supraphysiological concentrations stimulated blebbing of the plasma membrane. Subacute administration of doxorubicin (inductor of oxidative stress) decreased cell sensitivity to ATP, which corresponded to changes in membrane lipid peroxidation.

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Authors and Affiliations

  1. Department of Anatomy and Physiology of Agricultural Animals, Krasnoyarsk State Agrarian University, Russia

    Yu. A. Uspenskaya, A. B. Egorova & V. P. Nefedov

  2. Department of Pathophysiology and Functional Diagnostics, Krasnoyarsk State Medical Academy, Russia

    Yu. A. Uspenskaya, A. B. Egorova & V. P. Nefedov

Authors
  1. Yu. A. Uspenskaya
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  2. A. B. Egorova
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  3. V. P. Nefedov
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Correspondence to A. B. Egorova.

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Uspenskaya, Y.A., Egorova, A.B. & Nefedov, V.P. Doxorubicin Modulates Biological Effects of ATP in Bone Marrow Cells In Vitro. Bulletin of Experimental Biology and Medicine 133, 421–424 (2002). https://doi.org/10.1023/A:1019832914759

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  • DOI: https://doi.org/10.1023/A:1019832914759

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