Skip to main content
SpringerLink
Log in

Dyshormonal Disorders in Gout: Experimental and Clinical Studies

  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

A total of 107 patients with primary gout were examined. The pituitary-gonadal system is imbalanced in male patients with gout, which manifests by hyperproduction of progesterone and suppressed production of testosterone and estradiol. These changes are more pronounced in patients with chronic arthritis and proteinuric nephropathy. Similar dyshormonal changes are experimentally simulated in rats by induction of purine metabolism disorders. Exogenous injection of androgens in experimental hyperuricemia led to normalization of purine metabolism and hormonal homeostasis.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

REFERENCES

  1. E. F. Barinov, Pat. Fiziol., No. 4, 40–45 (1997).

  2. E. F. Barinov, O. V. Sinyachenko, N. N. Bondarenko, and O. I. Nikolenko, Vestn. Gig. Epidemiol., No. 2, 133–136 (1999).

  3. E. F. Barinov, O. V. Sinyachenko, V. A. Tolstoi, et al., Ortoped. Travmatol., No. 4, 118 (1994).

  4. Laboratory Methods of Investigation in Clinical Practice, Ed. V. V. Men'sjikov [in Russian], Moscow (1987).

  5. N. A. Mukhin, I. M. Balkarov, and M. V. Lebedeva, Ros. Med. Zh., No. 4, 18–23 (1998).

  6. T. M. Nenasheva, Voen.-Med. Zh., No. 2, 30–32 (1995).

  7. O. V. Sinyachenko, E. F. Barinov, T. Yu. Sinyachenko, et al., Vrach. Delo, No. 1, 58–60 (1994).

  8. O. V. Sinyachenko, E. N. Kosheleva, I. V. Mukhin, et al., Ter. Arkh., No. 10, 46–50 (1993).

  9. M. D. Harris, L. B. Siegel, and J. A. Alloway, Am. Fam. Physician, 59,No. 4, 925–934 (1999).

    Google Scholar 

  10. N. W. McGill, Bailliers Best Pract. Res. Clin. Rheumatol., 14,No. 3, 445–460 (2000).

    Google Scholar 

  11. T. Nakamura, Nippon Naika Gakkai Zasshi, 85,No. 9, 1520–1527 (1996).

    Google Scholar 

  12. M. Wyndham, Practitioner, 242,No. 1588, 546 (1998).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Donetsk State Medical University, Russia

    I. V. Mukhin, G. A. Ignatenko & V. Yu. Nikolenko

Authors
  1. I. V. Mukhin
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. G. A. Ignatenko
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. V. Yu. Nikolenko
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Mukhin, I.V., Ignatenko, G.A. & Nikolenko, V.Y. Dyshormonal Disorders in Gout: Experimental and Clinical Studies. Bulletin of Experimental Biology and Medicine 133, 491–493 (2002). https://doi.org/10.1023/A:1019826107916

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1023/A:1019826107916

Search

Navigation