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Endomorphin-2 Modulates Productions of TNF-α, IL-1β, IL-10, and IL-12, and Alters Functions Related to Innate Immune of Macrophages

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Abstract

We evaluate immunological effects of opioid peptide endomorphin-2 on the production of cytokines related to inflammation and Th1/Th2 balance, and functions related to innate immune of rat peritoneal macrophages. Endomorphin-2 inhibited TNF-α, IL-10, and IL-12 productions, but potentiated IL-1β production by macrophages. Moreover, endomorphin-2 potentiated macrophage adhesion to fibronectin, and the expression of adhesion molecule Mac-1 on macrophages. In contrast, endomorphin-2 suppressed phagocytosis of opsonized E. coli by macrophages, without affecting phagocytosis of non-opsonized E. coli. In addition, endomorphin-2 inhibited macrophage chemotaxis, and the production of superoxide anion by macrophages. These results suggest that endomorphin-2 may alter macrophage functions such as cytokine productions and functions related to innate immune.

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  1. Department of Pharmacology, Osaka Dental University, Hirakata, Osaka, 573-1121, Japan

    Yasutaka Azuma & Kiyoshi Ohura

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  1. Yasutaka Azuma
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Azuma, Y., Ohura, K. Endomorphin-2 Modulates Productions of TNF-α, IL-1β, IL-10, and IL-12, and Alters Functions Related to Innate Immune of Macrophages. Inflammation 26, 223–232 (2002). https://doi.org/10.1023/A:1019766602138

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