Skip to main content
SpringerLink
Log in

Acetyl-L-Carnitine: Biological Properties and Clinical Application (A Review)

  • Published:
Pharmaceutical Chemistry Journal Aims and scope

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

REFERENCES

  1. A. Marzo and S. Curti, J. Chromatogr. B. Biomed. Sci. Appl., 702(1-2), 1–20 (1997).

    Google Scholar 

  2. L. L. Bieber, R. Emaus, K. Valkner, et al., Fed. Proc., 41, 2852–2862 (1982).

    Google Scholar 

  3. R. Gatti, C. B. De Palo, P. Spinella, et al., Amino Acids, 14(4), 361–369 (1998).

    Google Scholar 

  4. D. Constantin-Teodosiu, S. Howell, and P. L. Greenhaff, J. Appl. Physiol., 80(3), 1061–1064 (1996).

    Google Scholar 

  5. G. Paradies, F. M. Ruggiero, G. Petrosillo, et al., FEBS Lett., 350(2-3), 213–215 (1994).

    Google Scholar 

  6. G. Paradies, Ruggiero F. M., G. Petrosillo, et al., Mech. Ageing Dev., 84(2), 103–112 (1995).

    Google Scholar 

  7. A. Shuaib, T. Wagaar, T. Wishart, et al., Neurochem. Res., 20(9), 1021–1025 (1995).

    Google Scholar 

  8. R. F. Butterworth, Dev. Neurosci., 20(4-5), 478–484 (1998).

    Google Scholar 

  9. L. Ratnakumari, I. A. Gureshi, D. Maysinger, et al., J. Pharmacol. Exp. Ther., 274(1), 437–443 (1995).

    Google Scholar 

  10. K. V. Rao, Y. R. Mawal, and I. A. Qureshi, Neurosci. Lett., 224(2), 83–86 (1997).

    Google Scholar 

  11. K. Gureshi, K. V. Rao, and I. A. Gureshi, Neurochem. Res., 23(6), 855–861 (1998).

    Google Scholar 

  12. Y. R. Mawal, K. V. Rama Rao, and I. A. Qureshi, Biochem. Pharmacol., 55(11), 1853–1860 (1998).

    Google Scholar 

  13. A. A. Sima, H. Ristic, A. Merry, et al., J. Clin. Invest., 97(8), 1900–1907 (1996).

    Google Scholar 

  14. J. I. Malone, S. Lowitt, A. F. Salem, et al., Metabolism, 45(7), 902–907 (1996).

    Google Scholar 

  15. M. A. Cotter, N. E. Cameron, A. Keegan, et al., Metabolism, 44(9), 1209–1214 (1995).

    Google Scholar 

  16. I. L. Soneru, T. Khan, Z. Orfalian, et al., Endocr. Res, 23(1-2), 27–36 (1997).

    Google Scholar 

  17. J. Nakamura, N. Koh, F. Sakakibara, et al., J. Pharmacol. Exp. Ther., 287(3), 897–902 (1998).

    Google Scholar 

  18. Y. Ido, J. McHowat, K. C. Chang, et al., Diabetes, 43(12), 1469–1477 (1994).

    Google Scholar 

  19. M. Kano, T. Kawakami, H. Hori, et al., Neurosci. Res., 33(3), 207–213 (1999).

    Google Scholar 

  20. M. J. Stevens, S. A. Lattimer, E. L. Feldman, et al., Metabolism, 45(7), 865–872 (1996).

    Google Scholar 

  21. E. Morabito, N. Corsico, A. Marzo, et al., Arzneimittelforsch., 44(8), 965–968 (1994).

    Google Scholar 

  22. E. Fernandes, R. Pallini, G. Tamburrini, et al., Neurol. Res., 17(5), 373–376 (1995).

    Google Scholar 

  23. E. Fernandes, R. Pallini, L. Lauretti, et al., Arch. Ital. Biol., 135(4), 343–351 (1997).

    Google Scholar 

  24. C. De Angelis C, C. Scarfo, and M. Falcinelli, Mech. Ageing Dev., 85(1), 37–53 (1995).

    Google Scholar 

  25. C. Bertoni-Freddari, P. Fatoretti, T. Casoli, et al., Brain Res., 656(2), 359–366 (1994).

    Google Scholar 

  26. C. Bertoni-Freddari, P. Fatoretti, U. Caselli, et al., Anal. Quant. Cytol. Histol., 18(4), 275–278 (1996).

    Google Scholar 

  27. P. L. Capecchi, F. Laghi Pasini, E. Quartarolo, et al., Vasc. Med., 2(2), 77–81 (1997).

    Google Scholar 

  28. G. Taglialatela, D. Navarra, M. T. Olivi A, et al., Neurochem. Res., 20(1), 1–9 (1995).

    Google Scholar 

  29. P. J. Foreman, J. R. Perez-Polo, L. Angelucci, et al., Prog. Neuropsychopharmacol. Biol. Psychiatry, 19(1), 117–133 (1995).

    Google Scholar 

  30. H. Kuratsune, Y. Watanabe, K. Yamaguti, et al., Biochem. Biophys. Res. Commun., 231(2), 488–493 (1997).

    Google Scholar 

  31. L. Vesci, P. Tobia, N. Corsico, et al., J. Neurochem., 64(6), 2783–2791 (1995).

    Google Scholar 

  32. R. Ricciolini, M. Scalibastri, J. K. Kelleher, et al., J. Neurochem., 71(6), 2510–2517 (1998).

    Google Scholar 

  33. T. Aureli, M. E. Di Cocco, C. Puccetti, et al., Brain Res., 769(1-2), 75–81 (1998).

    Google Scholar 

  34. A. Gorini, A. D' Angelo and R. F. Villa, Neuchem. Res., 23(12), 1485–1489 (1998).

    Google Scholar 

  35. M. A. Virmani, R. Conti, A. Spadoni, et al., Brain Res., 25(1-2), 105–112 (1994).

    Google Scholar 

  36. M. A. Virmani, R. Conti, A. Spadoni, et al., Pharmacol. Res., 31(3-4), 211–215 (1995).

    Google Scholar 

  37. A. Wawrzenczyk, K. A. Nalecz, and M. J. Nalecz, Biochem. Biophys. Res. Commun., 213(2), 383–388 (1995).

    Google Scholar 

  38. D. Terwel, J. Prickaerts, F. Meng, et al., Eur. J. Pharmacol., 287(1), 65–71 (1995).

    Google Scholar 

  39. J. Prickaerts, A. Blokland, W. Honing, et al., Brain Res., 674(1), 142–146 (1995).

    Google Scholar 

  40. A. Pascale, S. Milano, N. Corsico, et al., J. Eur. Pharmacol., 265(1-2), 1–7 (1994).

    Google Scholar 

  41. A. Caprioli, A. L. Markowska, and D. S. Olton, J. Gerontol. A. Biol. Sci. Med. Sci, 50(4), B 232–236 (1995).

    Google Scholar 

  42. G. Taglialatela, A. Caprioli, A. Giuliani, et al., Exp. Gerontol., 31(5), 577–587 (1996).

    Google Scholar 

  43. T. M. Hagen, R. T. Ingersoll, C. M. Werh, et al., Proc. Natl. Acad. Sci. USA, 95(16), 9562–9566 (1998).

    Google Scholar 

  44. M. Valoti, A. Benocci, K. Marazova, et al., Pharmacol. Res., 34(5-6), 219–224 (1996).

    Google Scholar 

  45. R. A. Howlett, M. L. Parolin, D. J. Dyck, et al., Am. J. Physiol., 275(2 Pt 2), R418–425 (1998).

    Google Scholar 

  46. I. A. Logvinenko, All-Russia Congr. “Humans and Drugs,” [in Russian], Moscow (1995), p. 305.

  47. M. M. Lolic, G. Fiskum, and R. E. Rosental, Ann. Emerg. Med., 29(6), 758–765 (1997).

    Google Scholar 

  48. E. Dell' Anna, L. Iuvone, S. Calzolari, et al., Neurosci Lett., 223(3), 201–205 (1997).

    Google Scholar 

  49. M. Onofrj, T. Fulgente, D. Melchionda, et al., Int. J. Clin. Pharmacol. Res., 15(1), 9–15 (1995).

    Google Scholar 

  50. G. J. Moyle and M. Sandler, Drug Saf., 19(6), 481–494 (1998).

    Google Scholar 

  51. G. Famularo, S. Moretti, S. Marselini, et al., AIDS, 11(2), 185–190 (1997).

    Google Scholar 

  52. R. Mazzocchio and A. Rossi, Brain Res. Brain Res. Protoc., 2(1), 53–58 (1997).

    Google Scholar 

  53. R. Mazzocchio and A. Rossi, Brain, 120(Pt 6), 991–1003 (1997).

    Google Scholar 

  54. L. J. Thal, A. Carta, and W. R. Clarke, Neurology, 47(3), 705–711 (1996).

    Google Scholar 

  55. J. O. Brooks, J. A. Yesavage, A. Carta, et al., Int. Psychogeriatr., 10(2), 193–203 (1998).

    Google Scholar 

  56. J. W. Pettegrew, W. E Klunk, K. Panchalingam, et al., Neurobiol. Aging, 16(1), 1–4 (1995).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Center for Drug Chemistry – All-Russia Research Institute of Pharmaceutical Chemistry, Moscow, Russia

    E. V. Efimova & T. A. Gus'kova

  2. State Research Institute of Vitamins, State Unitary Enterprise, Moscow, Russia

    V. M. Kopelevich & V. I. Gunar

Authors
  1. E. V. Efimova
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. T. A. Gus'kova
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. V. M. Kopelevich
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. V. I. Gunar
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Efimova, E.V., Gus'kova, T.A., Kopelevich, V.M. et al. Acetyl-L-Carnitine: Biological Properties and Clinical Application (A Review). Pharmaceutical Chemistry Journal 36, 111–115 (2002). https://doi.org/10.1023/A:1019689508012

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1023/A:1019689508012

Keywords

Search

Navigation