Abstract
The pathologic changes associated to response to primary chemotherapy in a series of 303 operable breast cancers are evaluated and correlated to patients' follow-up (interval free of disease and survival). In our series, the incidence of microscopic changes related to chemotherapy is 43.9%. Tumor replacement by loose fibrosis is the most common pathologic event. In most cases, the intensity of fibrotic change is proportional to the degree of clinical-mammographic reduction of the tumor mass. However, some discrepancies exist in the sense of absence of microscopic changes in cases of well-documented mammographic reduction as well as in cases without clinical reduction but with large areas of chemotherapy-related fibrosis. The presence of pathologic response is significantly associated with better survival rate.
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Hortobagyi GN, Ames FC, Buzdar AV, Kan SW, McNeese MD, Paulus D, Hug V, Holmes FA, Romsdahl MM, Fraschini G: Management of stage III primary breast cancer with primary chemotherapy, surgery and radiation therapy. Cancer 62: 2507–2516, 1988
Bonadonna G, Valagussa P: Primary chemotherapy in oper-able breast cancer. Semin Oncol 23: 464–474, 1996.
Fisher B, Byant J, Wolmark N, Mamounas E, Brown A, Fisher ER, Wickerham DL, Begovic M, DeCillis A, Robidoux A, Margolese RG, Cruz AB, Hoehn JL, Lees AW, Dimitrov NV, Bear HD: Effect of preoperative chemotherapy on the out-come of women with operable breast cancer. J Clin Oncol 16: 2675–2685, 1998
Bonadonnan G, Valagussa P, Brambilla C, Ferrari L, Moliterni A, Terenziani M, Zambetti M. Primary chemotherapy in oper-able breast cancer. Eight-year experience at the Milan Cancer Institute. J Clin Oncol 16: 93–100, 1998
Chollet P, Charrier S, Brain E, Curé H, van Praagh I, Feillel V, de Latour M, Dauplat J, Misset J-L, Ferrière J-P: Clinical and pathological response to primary chemotherapy in operable breast cancer. Eur J Cancer 33: 862–866, 1997
Fisher B, Brown A, Mamounas E, Wieand S, Robidoux A, Margolese RG, Cruz AB, Fisher ER, Wickerham DL, Wolmark N, DeCillis A, Hoehn JL, Lees AW, Dimitrov NV: Effect of preoperative chemotherapy on local-regional dis-ease in women with operable breast cancer. Findings from NSABP-18. J Clin Oncol 15: 2483–2493, 1997
Bonadonna G, Valagussa P, Zucali R, Salvadori B: Primary chemotherapy in surgically resectable breast cancer. CA Cancer J Clin 45: 227–243, 1995
Mauriac L, Durand M, Avril A, Dilhuydy JM: Effects of primary chemotherapy in conservative treatment of breast can-cer patients with operable tumors large than 3 cm: results of a randomised trial in a single centre. Ann Oncol 2: 347–354, 1991
Vinnicombe SJ, MacVicar AD, Guy RL, Sloane JP, Powles TJ, Knee G, Husband JE: Primary breast cancer: mammographic changes after neoadjuvant chemotherapy with pathologic correlation. Radiology 198: 333–340, 1996 0
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Moreno, A., Escobedo, A., Benito, E. et al. Pathologic Changes Related to CMF Primary Chemotherapy in Breast Cancer. Breast Cancer Res Treat 75, 119–125 (2002). https://doi.org/10.1023/A:1019607924403
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DOI: https://doi.org/10.1023/A:1019607924403