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Prevalence of mild impairment in renal function in a random sample of elders from a biethnic community survey

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Abstract

The purpose of this study was to compare theprevalences of renal impairment, notably anelevation in serum urea nitrogen and/or serumcreatinine concentration, in a randomlyselected, biethnic population of Hispanic andnon-Hispanic white men and women, and todetermine the associations with coronary heartdisease and its risk factors (diabetes,hypertension, and dyslipidemia). A survey ofhealth and health-related issues was conductedon 883 volunteers, mean age 74.1 years,randomly selected from the Medicare rolls ofBernalillo County (Albuquerque), New Mexico. Equal numbers of Hispanic and non-Hispanicwhite men and women were selected andrecruited. A fasting serum creatinine andserum urea nitrogen was included in the batteryof laboratory tests.Mild elevations of SUN and serum creatinineconcentrations are common (9.2%) in an aging,randomly selected population (mean age 74.1years). Males were more commonly affected thanfemales. There were no differences betweenHispanics and non-Hispanic whites, even thoughdiabetes was twice as prevalent in Hispanics. Mild elevations of SUN and serum creatininewere more common in participants with coronaryheart disease and its risk factors (diabetes,hypertension, and dyslipidemia). Allparticipants with mild renal impairment hadeither increased total cholesterol or decreasedHDL-cholesterol.One cannot determine from a cross-sectionalstudy whether the dyslipidemia consistentlyassociated with mild renal impairment was acause of the renal impairment or a result ofthe renal impairment; however, biologicalexplanations do exist to explain how thedyslipidemias can lead to progressiveglomerulosclerosis.

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Authors and Affiliations

  1. From the Departments of Internal Medicine, Family and Community Medicine, and Pathology, and Clinical Nutrition Program, University of New Mexico School of Medicine, Albuquerque, New Mexico, USA

    Robert D. Lindeman, Linda J. Romero, C. Lillian Yau, Richard N. Baumgartner & Philip J. Garry

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  1. Robert D. Lindeman
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  2. Linda J. Romero
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  3. C. Lillian Yau
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  4. Richard N. Baumgartner
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  5. Philip J. Garry
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Lindeman, R.D., Romero, L.J., Yau, C.L. et al. Prevalence of mild impairment in renal function in a random sample of elders from a biethnic community survey. Int Urol Nephrol 33, 553–557 (2001). https://doi.org/10.1023/A:1019590416234

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