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REFERENCES
M. F. Piercey, R. A. Lahti, L. A. Schroeder, F. J. Einspahr, and C. Barsuhn. U-50,488H, a pure kappa receptor agonist with spinal analgesic loci in the mouse. Life Sci. 31:1197–1200 (1982).
P. F. VonVoigtlander and R. A. Lewis. Analgesic and mechanistic evaluation of spiradoline, a potent kappa opioid. J. Pharmacol. Exp. Ther. 246:259–262 (1988).
J. C. Hunter, G. E. Leighton, K. G. Meecham, S. J. Boyle, D. C. Horwell, D. C. Rees, and J. Hughes. CI-977, a novel and selective agonist for the kappa-opioid receptor. Br. J. Pharmacol. 101:183–189 (1990).
P. Rajagopalan, R. M. Scribner, P. Pennev, W. K. Schmidt, S. W. Tam, G. F. Steinfels, and L. Cook. DuP 747. A new, potent, kappa opioid analgesic. Synthesis and pharmacology. Bioorg. Med. Chem. Lett. 2:715–720 (1992).
W. R. Martin, C. G. Eades, J. A. Thompson, R. E. Huppler, and P. E. Gilbert. The effects of morphine-and nalorphine-like drugs in the nondependent and morphine-dependent chronic spinal dog. J. Pharmacol. Exp. Ther. 197:517–532 (1976).
M. J. Millan. k-Opioid receptors and analgesia. Trends Pharm. Sci. 11:70–76 (1990).
J. H. Jaffe and W. R. Martin. Opioid analgesics and antagonists. In A. G. Gilman, T. W. Rall, A. S. Nies, and P. Taylor (eds.), Goodman and Gilman's the Pharmacological Basis of Therapeutics, 8th ed., Pergamon Press, New York, 1990, pp. 485–521.
W. K. Schmidt, L. C. Johnson, M. E. Marynowski, P. Rajagopalan, R. M. Scribner, G. F. Steinfels, S. W. Tam, and L. Cook. DuP 747: Review of the pharmacology of a kapa-selective analgesic (submitted for publication).
P. Rajagopalan, R. M. Scribner, P. Pennev, P. L. Mattei, H. S. Kezar, C. Y. Cheng, R. S. Cheeseman, V. R. Ganti, A. L. Johnson, M. A. Wuonola, W. K. Schmidt, S. W. Tam, G. F. Steinfels, and L. Cook. DuP 747: SAR study. Bioorg. Med. Chem. Lett. 2:721–726 (1992).
A. Hussain, S. Hirai, and R. Bawarshi. Nasal absorption of propranolol in rats. J. Pharm. Sci. 68:196 (1979).
M. A. Hussain and J. A. Mollica. Intranasal absorption of physostigmine and arecoline. J. Pharm. Sci. 80:750–751 (1991).
Anon. Nasal spray analgesic approved. Anesthesiol. Rev. 19:13 (1992).
T. K. Abboud, J. Zhu, J. Gangolly, M. Longhitano, F. Swart, A. Makar, G. Chu, M. Cool, M. Mantilla, N. Kurtz, and L. Reich. Transnasal butorphanol: a new method for pain relief in post-cesarean section pain. Acta Anaesthesiol. Scand. 35:14–18 (1991).
H. Blumberg, P. S. Wolf, and H. B. Dayton. Use of writhing test for evaluating analgesic activity of narcotic antagonists. Proc. Soc. Exp. Biol. Med. 118:763–766 (1965).
W. R. Thompson. Use of moving averages and interpolation to estimate median effective dose. I. Fundamental formulas, estimation of error, and relation to other methods. Bact. Rev. 11:115–145 (1947).
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Hussain, M.A., Schmidt, W.K. & Buehler, J.D. Intranasal Absorption of a Kappa Agonist Analgesic. Pharm Res 10, 1083–1086 (1993). https://doi.org/10.1023/A:1018987328143
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DOI: https://doi.org/10.1023/A:1018987328143