Skip to main content

Advertisement

SpringerLink
Log in

Interaction of Zidovudine (Azidothymidine) with Isoprinosine and Probenecid in Macaca fascicularis

  • Note
  • Published:
Pharmaceutical Research Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

REFERENCES

  1. B. A. Larder and D. G. Richman. HIV with reduced sensitivity to zidovudine (AZT) isolated during prolonged therapy. Science 243:1731–1734 (1989).

    CAS  PubMed  Google Scholar 

  2. H. D. Langtry and D. M. Campoli-Richards. Zidovudine: A review of its pharmacodynamic and pharmacokinetic properties and therapeutic efficacy. Drugs 37:408–450 (1989).

    Google Scholar 

  3. D. M. Campoli-Richards, E. M. Sorkin, and R. C. Heel. Inosine Pranobex: A preliminary review of its pharmacodynamic and pharmacokinetic properties and therapeutic efficacy. Drugs 32:383–424 (1986).

    Google Scholar 

  4. C. DeSimone, S. Tzantzoglou, V. Vullo, S. Catania, and V. Trinchieri. Inosine Pranobex and zidovudine metabolism. Lancet 2:977–978 (1989).

    Google Scholar 

  5. A. Pompidou, J. Lang, L. Telvi, M. Delsaux, and P. Sarin. Influence of immunomodulators on T lymphocyte differentiation in ARC patients and resistance to LAV/HTLV III infection. Comp. Immunol. Microbiol. Infect. Dis. 9:263–267 (1986).

    Google Scholar 

  6. R. F. Schinazi, D. L. Cannon, B. H. Arnold, and D. Martino-Saltzman. Combinations of isoprinosine and 3′-azido-3′-deoxythymidine in lymphocytes infected with human immunodeficiency virus type 1. Antimicrob. Agents Chemother. 32:1784–1787 (1988).

    Google Scholar 

  7. J. G. Bekesi, P. H. Tsang, J. I. Wallace, and J. P. Roboz. Immunorestorative properties of isoprinosine in the treatment of patients at high risk of developing ARC or AIDS. J. Clin. Lab. Immunol. 24:155–161 (1987).

    Google Scholar 

  8. C. DeSimone, M. Ferrazzi, F. Bitonti, M. Falciano, S. Tzantzoglou, S. Delia, and F. Sorice. Pharmacokinetics of zidovudine and concomitant inosine-pranobex in AIDS patients. Immunopharmacol. Immunotoxicol. 10 (4):437–441 (1988).

    Google Scholar 

  9. M. A. Hedaya, W. F. Elmquist, and R. J. Sawchuk. Probenecid inhibits the metabolic and renal clearances of zidovudine (AZT) in human volunteers. Pharm. Res. 7:411–417 (1990).

    Google Scholar 

  10. A. Lopez-Anaya, J. D. Unadkat, L. A. Schumann, and A. L. Smith. Pharmacokinetics of zidovudine (azidothymidine). I. Transplacental transfer. J. AIDS 3:959–964 (1990).

    Google Scholar 

  11. M. Gibaldi and D. Perrier. Pharmacokinetics, 2nd ed., Marcel Dekker, New York, 1982, pp. 409–416.

    Google Scholar 

  12. P. de Miranda, S. S. Good, R. Yarchoan, R. V. Thomas, R. Blum, C. E. Myers, and S. Broder. Alteration of zidovudine pharmacokinetics by probenecid in patients with AIDS or AIDS-related complex. Clin. Pharmacol. Ther. 46:494–500 (1989).

    Google Scholar 

  13. M. A. Hedaya and R. J. Sawchuk. Effect of probenecid on the renal and nonrenal clearances of zidovudine and its distribution into cerebrospinal fluid in the rabbit. J. Pharm. Sci. 78:716–722 (1989).

    Google Scholar 

  14. J.-Y. Chatton, M. Odone, K. Besseghir, and F. Rah-Ramel. Renal secretion of 3′-azido-3′-deoxythymidine by the rat. J. Pharmacol. Exp. Ther. 255:140–145 (1990).

    Google Scholar 

  15. A. Lopez-Anaya, J. D. Unadkat, L. A. Schumann, and A. L. Smith. Pharmacokinetics of zidovudine (azidothymidine). II. Development of metabolic and renal clearance pathways in the neonate. J. AIDS 3:1052–1058 (1990).

    Google Scholar 

  16. A. Lopez-Anaya, J. D. Unadkat, L. A. Schumann, and A. L. Smith. Pharmacokinetics of zidovudine (azidothymidine). III. Effect of pregnancy. J. AIDS 4:64–68 (1991).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pharmaceutics, School of Pharmacy, University of Washington, Seattle, Washington, 98195

    Sayed M. H. Al-Habet, Connie Nosbisch, Tracy Williamson & Jashvant D. Unadkat

  2. Regional Primate Research Center, University of Washington, Seattle, Washington, 98195

    Che-Chung Tsai & Jashvant D. Unadkat

Authors
  1. Sayed M. H. Al-Habet
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Connie Nosbisch
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Tracy Williamson
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Che-Chung Tsai
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Jashvant D. Unadkat
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Al-Habet, S.M.H., Nosbisch, C., Williamson, T. et al. Interaction of Zidovudine (Azidothymidine) with Isoprinosine and Probenecid in Macaca fascicularis . Pharm Res 11, 181–183 (1994). https://doi.org/10.1023/A:1018982703049

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1023/A:1018982703049

Search

Navigation