Skip to main content
SpringerLink
Log in

Formation of a Chromophoric Complex Between Alendronate and Copper(II) Ions

  • Note
  • Published:
Pharmaceutical Research Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

REFERENCES

  1. E. W. Tsai, D. P. Ip, and M. A. Brooks. Determination of alendronate in pharmaceutical dosage formulations by ion-exchange high-performance liquid chromatography with conductivity detection. J. Chromatogr. 596:217–224 (1992).

    Google Scholar 

  2. P. T. Daley-Yates, L. A. Gifford, and C. R. Hoggarth. Assay of 1-hydroxy-3-aminopropylidene-1,1-bisphosphonate and related bisphosphonates in human urine and plasma by high performance ion chromatography. J. Chromatogr. 490:329–338 (1989).

    Google Scholar 

  3. T. L. Chester, E. C. Lewis, J. J. Benedict, R. J. Sunberg, and W. C. Tettenhorst. Determination of (dichloromethylene)-diphosphonate in physiological fluids by ion-exchange chromatography with phosphorous-selective detection. J. Chromatogr. 225:17–25 (1981).

    Google Scholar 

  4. D. J. Harvey and M. G. Horning. Derivatives for the characterization of alkyl-and amino-alkylphosphonates by gas chromatography and gas chromatography-mass spectrometry. J. Chromatogr. 79:65–74 (1973).

    Google Scholar 

  5. Z. Ismail, S. Aldous, E. J. Triggs, B. A. Smithurst, and H. D. Barry. Gas chromatographic analysis of didronel tablets. J. Chromatogr. 404:372–377 (1987).

    Google Scholar 

  6. J. D. DeMarco, S. E. Biffar, D. G. Reed, and M. A. Brooks. The determination of 4-amino-1-hydroxybutane-1,1-bisphosphonic acid monosodium salt trihydrate in pharmaceutical dosage forms by high-performance liquid chromatography. J. Pharm. Biomed. Anal. 7:1719–1727 (1989).

    Google Scholar 

  7. W. F. Kline, B. K. Matuszewski, and W. F. Bayne. Determination of 4-amino-1-hydroxybutane-1,1-bisphosphonic acid in urine by automated pre-column derivatization with 2,3-naphthalene dicarboxaldehyde and high-performance liquid chromatography with fluorescence detection. J. Chromatogr. 534:139–149 (1990).

    Google Scholar 

  8. E. Kwong, A. M. Y. Chiu, S. A. McClintock, and M. L. Cotton. HPLC analysis of an amino bisphosphonate in pharmaceutical formulations using post-column derivatization and fluorescence detection. J. Chromatogr. Sci. 28:563–566 (1990).

    Google Scholar 

  9. G. Flesch and S. A. Hauffe. Determination of the bisphosphonate pamidronate disodium in urine by pre-column derivatization with fluorescamine, high-performance liquid chromatography and fluorescence detection. J. Chromatogr. 489:446–451 (1989).

    Google Scholar 

  10. N. Nardelli and G. Pelizzi. A structural study on metal binding of gem-diphosphonates, bone growth regulators. Inorg. Chim. Acta 80:259–271 (1983).

    Google Scholar 

  11. M. L. Lamson, J. L. Fox, and W. I. Higuchi. Calcium and 1-hydroxyethylidene-1,1-bisphosphonic acid:polynuclear complex formation in the physiological range of pH. Int. J. Pharm. 21:143–154 (1984).

    Google Scholar 

  12. H. Wada and Q. Fernando. Determination of formation constants of copper(II) complexes of ethane-1-hydroxy-1,1-diphosphonic acid with a solid state cupric ion-selective electrode. Anal. Chem. 43:751–755 (1971).

    Google Scholar 

  13. H. Erlenmeyer, R. Griesser, B. Prijs, and H. Sigel. Zur Metallion-Komplexbildung fünfgliedriger α-Carboxy-Heterocyclen. Helv. Chim. Acta 51:339–348 (1968).

    Google Scholar 

  14. E. W. Tsai, M. M. Singh, H. H. Lu, D. P. Ip, and M. A. Brooks. Application of capillary electrophoresis to pharmaceutical analysis: Quantitative analysis of alendronate in dosage forms. J. Chromatogr. 626:245–250 (1992).

    Google Scholar 

Download references

Author information

Author notes

  1. Becky Hulshizer

    Present address: Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania, 19104

Authors and Affiliations

  1. Pharmaceutical Research and Development Department, Merck Research Laboratories, West Point, Pennsylvania, 19486

    Dražen Ostović & Christine Stelmach

Authors
  1. Dražen Ostović
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Christine Stelmach
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Becky Hulshizer
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Ostović, D., Stelmach, C. & Hulshizer, B. Formation of a Chromophoric Complex Between Alendronate and Copper(II) Ions. Pharm Res 10, 470–472 (1993). https://doi.org/10.1023/A:1018969112754

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1023/A:1018969112754

Search

Navigation