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Solid-State Nuclear Magnetic Resonance Spectroscopy: Theory and Pharmaceutical Applications

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Abstract

The theory of solid-state nuclear magnetic resonance (NMR) spectroscopy is reviewed, with specific discussions of magnetic interactions in the solid state. Each magnetic interaction (Zeeman, dipole-dipole, chemical-shift, spin–spin, and quadrupolar) is addressed and manifestations of these interactions in the solid state NMR spectrum are explained. The techniques of high-power decoupling, magic-angle spinning, and cross-polarization, used to acquire highly resolved solid-state NMR spectra, are also illustrated. Application of solid-state NMR to pharmaceutical problem solving and methods development is then briefly reviewed.

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  1. Bristol-Myers Squibb Pharmaceutical Research Institute, 1 Squibb Drive, P.O. Box 191, New Brunswick, New Jersey, 08903-0191

    David E. Bugay

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Bugay, D.E. Solid-State Nuclear Magnetic Resonance Spectroscopy: Theory and Pharmaceutical Applications. Pharm Res 10, 317–327 (1993). https://doi.org/10.1023/A:1018967717781

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