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Axial Ratio Measurements for Early Detection of Crystal Growth in Suspension-Type Metered Dose Inhalers

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REFERENCES

  1. E. M. Phillips, P. R. Byron, K. Fults, and A. J. Hickey. Optimized inhalation aerosols. II. Inertial testing methods for particle size analysis of pressurized inhalers. Pharm. Res. 7:1228–1233 (1990).

    Google Scholar 

  2. E. M. Phillips. Effect of Formulation Variables upon Drug Solubility in Inhalation Aerosol Propellants: Relationship to Crystal Growth in Metered Dose Inhalers, Ph.D. thesis, Virginia Commonwealth University, Richmond, 1991.

    Google Scholar 

  3. M. Akbarieh and R. Tawashi. Morphic features of solid particles after micronization in the fluid energy mill. Int. J. Pharm. 35:81–89 (1987).

    Google Scholar 

  4. R. N. Dalby, E. M. Phillips, and P. R. Byron. Determination of drug solubility in aerosol propellants. Pharm. Res. 8:1206–1209 (1991).

    Google Scholar 

  5. T. Allen. Microscopy. In T. Allen (ed.), Particle Size Measurement, 2nd ed., Chapman and Hall Ltd., 1974, pp. 127–139.

  6. Metaproterenol sulfate inhalation aerosol monograph. USP XXII, 1990, p. 836.

  7. J. K. Haleblian. Characterization of habits and crystalline modification of solids and their pharmaceutical applications. J Pharm. Sci. 64:1269–1288 (1975).

    Google Scholar 

  8. P. H. Elworthy and H. E. C. Worthington. The particle size of sulfathiazine produced by a solvent change method. J. Pharm. Pharmacol. 23:101S (1971).

    Google Scholar 

  9. R. S. Tipson. In A. Weissberger (ed.), Separation and Purification Part I, Vol. III, Interscience, New York, 1956, p. 433.

    Google Scholar 

  10. I. R. Brown, P. York, and J. Q. Maclaine. The role of crystallisation conditions in the control of final product size. J Pharm. Pharmacol. 40:61P (1989).

    Google Scholar 

  11. T. A. Barber, M. D. Lannis, and J. G. Williams. Method evaluation: Automated microscopy as a compendial test for particulates in parenteral solutions. J. Parent. Sci. Tech. 43:27–47 (1989).

    Google Scholar 

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Author notes

  1. Elaine M. Phillips

    Present address: Pharmaceutical Research and Development, Hoffmann-La Roche, Nutley, New Jersey

Authors and Affiliations

  1. The Aerosol Research Group, Department of Pharmacy and Pharmaceutics, Virginia Commonwealth University, Box 533, Richmond, Virginia, 23298

    Elaine M. Phillips, Peter R. Byron & Richard N. Dalby

Authors
  1. Elaine M. Phillips
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  2. Peter R. Byron
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  3. Richard N. Dalby
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Phillips, E.M., Byron, P.R. & Dalby, R.N. Axial Ratio Measurements for Early Detection of Crystal Growth in Suspension-Type Metered Dose Inhalers. Pharm Res 10, 454–456 (1993). https://doi.org/10.1023/A:1018960910937

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