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The Influence of Blood Sampling Site in Nasal Drug Delivery Studies in Rats

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REFERENCES

  1. F. LaPeyrac. Taking of blood from the cavernous sinus. Rev. Etud. Clin. Biol. 8:195–196 (1963).

    Google Scholar 

  2. V. Riley. Adaptation of orbital bleeding technic to rapid serial blood studies. Proc. Soc. Exp. Biol. Med. 104:751–754 (1960).

    Google Scholar 

  3. S. Stone. Method for obtaining venous blood from the orbital sinus of the rat or mouse. Science 119:100 (1954).

    Google Scholar 

  4. T. Nobunaga, K. Nabamura, and T. Imamichi. A method for intravenous injection and collection of blood from rats and mice without restraint and anesthesia. Lab. Anim. Care 16:40–49 (1966).

    Google Scholar 

  5. H. Grice. Methods for obtaining blood and for intravenous injections in laboratory animals. Lab. Anim. Care 14:483–493 (1964).

    Google Scholar 

  6. A. Moreland. Collection and withdrawal of body fluids and infusion techniques. In W. Gay (ed.), Methods of Animal Experimentation. Academic Press, New York, 1965, pp. 1–42.

    Google Scholar 

  7. R. Kassel and S. Levitan. A jugular technique for the repeated bleeding of small animals. Science 118:563–564 (1953).

    Google Scholar 

  8. S. Nerenberg and P. Zedler. Sequential blood samples from the tail vein of rats and mice obtained with modified Liebig condenser jackets and vacuum. J. Lab. Clin. Med. 85:523–526 (1975).

    Google Scholar 

  9. A. Hurwitz. A simple method for obtaining blood samples from rats. J. Lab. Clin. Med. 78:172–174 (1971).

    Google Scholar 

  10. A. Pettit. Procédé simple pour prélever du sang chez les petits rongeurs. Compt. Rend. Soc. Biol. 74:11–12 (1913).

    Google Scholar 

  11. A. Daugherty, H. Liggit, J. McCabe, J. Moore, and J. Patton. Absorption of recombinant methionyl-human growth hormone (Met-hGH) from rat nasal mucosa. Int. J. Pharm. 45:197–206 (1988).

    Google Scholar 

  12. E. Karasek, R. Rathsack, K. Fechner, and M. Gräfenberg. Nasal absorption of Substance P in rats. Pharmazie 41:289–290 (1986).

    Google Scholar 

  13. M. Rocci and W. Jusko. LAGRAN program for area and moments in pharmacokinetic analysis. Comput. Progr. Biomed. 16:203–216 (1983).

    Google Scholar 

  14. W. L. Chiou. The phenomenon and rationale of marked dependence of drug concentration on blood sampling site. Implications in pharmacokinetics, pharmacodynamics, toxicology and therapeutics (Parts I and II). Clin. Pharmacokinet. 17:175–199, 275–290 (1989).

    Google Scholar 

  15. E. Greene. In E. Greene (ed.), Anatomy of the Rat, Hafner, New York & London, 1963, pp. 214–247.

    Google Scholar 

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Authors and Affiliations

  1. Pharmaceutical Research and Development, Hoffmann-La Roche, Inc., Nutley, New Jersey, 07110

    Hing Char, Saran Kumar, Giuseppe Ciccone, David Piemontese, A. Waseem Malick & Charan R. Behl

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  1. Hing Char
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  2. Saran Kumar
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  3. Giuseppe Ciccone
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  4. David Piemontese
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  5. A. Waseem Malick
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  6. Charan R. Behl
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Char, H., Kumar, S., Ciccone, G. et al. The Influence of Blood Sampling Site in Nasal Drug Delivery Studies in Rats. Pharm Res 10, 1378–1380 (1993). https://doi.org/10.1023/A:1018942402160

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