Abstract
Evaluation of 13-cis-12-substituted analogues of retinoic acid in a series of dermatologic screens has revealed that structural modifications can lead to selectivity and specificity. An analogue, 11-cis,13-cis-12-hydroxymethylretinoic acid, δ-lactone, has been found to have good activity and to be devoid of topical and systemic toxicity.
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Lewin, A.H., Bos, M.E., Zusi, F.C. et al. Evaluation of Retinoids as Therapeutic Agents in Dermatology. Pharm Res 11, 192–200 (1994). https://doi.org/10.1023/A:1018938920796
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DOI: https://doi.org/10.1023/A:1018938920796