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Pharmaceutical Research

, Volume 9, Issue 2, pp 255–259 | Cite as

Development and Evaluation of a Novel Dissolution Apparatus for Medicated Chewing Gum Products

  • James N. Rider
  • Ed L. Brunson
  • Walter G. Chambliss
  • Robert W. Cleary
  • Ahmed H. Hikal
  • Peggy H. Rider
  • Larry A. Walker
  • Christy M. Wyandt
  • Alan B. Jones
Article

Abstract

A novel dissolution apparatus was developed for medicated chewing gum products. A prototype gum product containing phenylpropa-nolamine hydrochloride (PPA) was used to evaluate the apparatus. The apparatus consists of a conical Teflon base and a rotating, ribbed Teflon plunger suspended in a dissolution vessel. Parameters evaluated were rotation speed, plunger frequency, medium volume, medium type, medium sampling location, number of plunger ribs, and number of gum pieces. Samples were taken over a 20-min period and samples were analyzed by HPLC. Cumulative percentage re-leased-versus-time profiles were obtained for each parameter evaluated. Statistical analysis of the gum product indicated that the only significant differences occurred at the lowest rotation speed and lowest plunger frequencies. A Level A correlation was found between the in vitro release profile for the 20-rpm and 30-cycles/min plunger frequency and the in vivo chew-out study.

dissolution chewing gum phenylpropanolamine hydrochloride in vitro-in vivo correlation 

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Copyright information

© Plenum Publishing Corporation 1992

Authors and Affiliations

  • James N. Rider
    • 1
  • Ed L. Brunson
    • 2
  • Walter G. Chambliss
    • 2
  • Robert W. Cleary
    • 1
    • 3
  • Ahmed H. Hikal
    • 1
    • 3
  • Peggy H. Rider
    • 1
  • Larry A. Walker
    • 3
  • Christy M. Wyandt
    • 1
    • 3
  • Alan B. Jones
    • 1
    • 3
  1. 1.Department of PharmaceuticsUniversity of Mississippi
  2. 2.Pharmaceutical Research and DevelopmentSchering-Plough Health Care ProductsMemphis
  3. 3.Research Institute of Pharmaceutical SciencesUniversity of Mississippi

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