Abstract
Portal hypertensive gastropathy is awell-established clinical entity. Although stimulatedacid secretion has been found to be decreased in portalhypertensive rats, the parietal cell mass has not been studied. Portal hypertension was produced inWistar rats either by partial portal vein ligation (N =16) or by common bile duct ligation (N = 23) andconfirmed by intrasplenic pulp pressure measurement. The parietal cells were isolated and counted in aNeubaur hemacytometer. The parietal cell count was alsodone in microscopic sections at direct histopathologicalexamination. The viable, isolated parietal cell count and parietal cell count onhistopathological examination were significantlydecreased in partial portal vein ligated rats.Similarly, in common bile duct ligated rats, theparietal cell count was decreased as compared to sham-operatedrats. In experimental portal hypertensive gastropathythere is a decrease in parietal cell number.
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Agnihotri, N., Kaur, S., Dilawari, J.B. et al. Diminution in Parietal Cell Number in Experimental Portal Hypertensive Gastropathy. Dig Dis Sci 42, 431–439 (1997). https://doi.org/10.1023/A:1018898826201
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DOI: https://doi.org/10.1023/A:1018898826201