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Interleukin-6 and Small Intestinal Luminal Immunoglobulins

Digestive Diseases and Sciences volume 43, pages 442–445 (1998)Cite this article

Abstract

Our aim was to determine the relationshipsbetween interleukin-6 and immunoglobulin levels withinsmall intestinal luminal secretions. Twenty adultsubjects with small intestinal bacterial overgrowth (N= 13), irritable bowel syndrome (N = 4), and nonulcerdyspepsia (N = 3) underwent endoscopic aspiration ofsecretions from the small intestinal mucosal surface forassessment of IL-6, IgA1, IgA2,IgM, IgG1, IgG2, IgG3,and IgG4 concentrations. Serum immunoglobulinconcentrations and small intestinal histology were alsodetermined. IgA2 and IgG3 were thepredominant IgA1 and IgG1subclasses in luminal secretions in 19/20 (95%) and 20/20 (100%) subjects,respectively. IgA2 and IgG3predominated in serum in all subjects. No subject hadvillous atrophy. Luminal IL-6 concentrations correlatedsignificantly with luminal IgA2, IgM, and IgG3concentrations but not with IgA2 or any otherIgG3 subclass levels. Conversely, luminalIL-6 or immunoglobulin concentrations did not correlatesignificantly with levels of any immunoglobulin isotype in serum. These observations suggestthat important relationships exist between local IL-6and IgA2, IgM, and IgG3 responsesin human small intestinal luminal secretions. Localinvestigation is mandatory when assessing intestinal immuneactivity.

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Authors
  1. Stephen M. Riordan
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  2. Christopher J. Mciver
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  3. Denis Wakefield
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  4. Mervyn C. Thomas
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  5. Vic M. Duncombe
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  6. Terry D. Bolin
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Riordan, S.M., Mciver, C.J., Wakefield, D. et al. Interleukin-6 and Small Intestinal Luminal Immunoglobulins. Dig Dis Sci 43, 442–445 (1998). https://doi.org/10.1023/A:1018891313829

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  • DOI: https://doi.org/10.1023/A:1018891313829

  • INTERLEUKIN-6
  • SMALL INTESTINE
  • LUMINAL IMMUNOGLOBULINS