Abstract
The aim of this study was to assess therelationship between fasting antral distension and basaland maximal acid output and to examine the link betweenthe gastric emptying rate of liquids and the amount of acid secretion. Twenty consecutive malepatients with H. pylori positive noncomplicated duodenalulcer disease received a measurement of basal andmaximal gastric acid secretion and underwentultrasonographic (US) evaluation of fasting antral distensionand gastric emptying of liquids on two separate days.Ten of these patients were studied again three monthsafter ulcer healing. The width of the fasting antral area was not correlated with basal acid output,but a significant relationship was found between maximalacid output and fasting antral distension (r = 0.55; P= 0.012). No significant correlations were found between gastric emptying and gastric acidoutput. The gastric emptying rate, expressed ashalf-time gastric emptying and remaining liquidcomponent at 60 min, was not influenced by basal ormaximal acid output. After ulcer healing, no correlationswere found between acid secretion, fasting antraldistension, and gastric emptying rate. Our resultssuggest that in duodenal ulcer patients, fasting antral distension is not influenced by basal gastricsecretion and that, on the contrary, a correlationexists between fasting antral distension and maximalacid output, but only in active duodenal ulcer. Norelationship exists in both active and healed duodenal ulcerbetween gastric emptying and gastric acidsecretion.
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Maconi, G., Manzionna, G. & Porro, G.B. Relationship Among Acid Secretion, Antral Distension, and Liquid Gastric Emptying in Active and Healed Duodenal Ulcer. Dig Dis Sci 42, 2426–2431 (1997). https://doi.org/10.1023/A:1018883722181
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DOI: https://doi.org/10.1023/A:1018883722181