Skip to main content
SpringerLink
Log in

Effects of Pregnancy in Rats on Cysteamine-Induced Peptic Ulcers (Role of Progesterone)

  • Published:
Digestive Diseases and Sciences Aims and scope Submit manuscript

Abstract

After mating with a sexually active male, groupsof female Sprague-Dawley rats were injected withcysteamine (400 mg/kg, subcutaneously) at day 0(controls), day 5 (early-stage pregnancy), and day 18(late-stage pregnancy) of pregnancy. In contrast tolate-stage pregnancy rats, early-stage pregnancy animalsshowed a decrease of cysteamine-induced gastroduodenallesions. When subjected to cysteamine injection, both nonpregnant female and male rats treated foreight days with progesterone (300 μg/rat,subcutaneously) showed a reduced incidence ofgastroduodenal lesions. No effect was found in animalspretreated with 17β-estradiol (200 μg/rat,subcutaneously). Furthermore, increased gastroduodenalmucus levels were found in early-stage pregnancy ratsand in animals pretreated with progesterone. Theseresults suggest that increased progesterone plasma levelsduring early-stage pregnancymay be involved inpregnancy-induced gastric and duodenal protection. Thiseffect may be related to an increase in gastric andduodenal mucus production induced by thishormone.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

REFERENCES

  1. Michaletz Onody PA: Peptic ulcer disease in pregnancy. Gastroenterol Clin North Am 21:817–826, 1992

    Google Scholar 

  2. Aston NO, Kalaichandran S, Carr JV: Duodenal ulcer hemorrhage in the puerperium. Can J Surg 34:482–483, 1991

    Google Scholar 

  3. Furukawa O, Takeuchi K, Nishiwaki H, Okabe S: Pathogenesis of digitoxin-induced duodenal ulcers in pregnant rats. Roles of gastric acid and duodenal alkaline secretion. Dig Dis Sci 33:889–896, 1988

    Google Scholar 

  4. de Ziegler D: Hormonal control of endometrial receptivity. Hum Reprod 10:4–7, 1995

    Google Scholar 

  5. Rao AJ, Prasad KS, Sharma SC, Subbarayan VS: Role of 17 beta-estradiol and progesterone in the regulation of synthesis and secretion of chorionic gonadotropin by the first trimester human placenta. J Steroid Biochem Mol Biol 53:233–239, 1995

    Google Scholar 

  6. Drago F, Montoneri C: Growth hormone and somatostatin interaction in the ulcerogenic effect of cysteamine in female rats. J Physiol (in press)

  7. Corne SJ, Morrisey SM, Woods RJ: A method for the quantitative estimation of gastric barrier mucus. J Physiol 242:166–167, 1974

    Google Scholar 

  8. Elegbe RA: Inactivation of prostaglandin E2 in the stomach of pregnant and oestrogen pretreated rats. Biochem Exp Biol 14:69–76, 1978

    Google Scholar 

  9. Bernardini MC, Blandizzi C, Morini G, Chiavarini M, Impicciatore M, Del Tacca M: Pirenzepine prevents cysteamine-induced formation of gastroduodenal ulcers and reduction of mesenteric circulation. Arch Int Pharmacodyn 302:242–254, 1989

    Google Scholar 

  10. Groves WG, Schlossen JH, Mead FD: Acid hypersecretion and duodenal ulcers produced by cysteamine in rats. Res Commun Chem Pathol Pharmacol 9:523–534, 1974

    Google Scholar 

  11. Szabo S, Reynolds ES, Lightenberger LM, Dzan VJ: Pathogenesis of duodenal ulcer. Gastric hyperacidity caused by propionitrile and cysteamine in rats. Res Commun Chem Pathol Pharmacol 16:311–322, 1976

    Google Scholar 

  12. McIntosh C, Backich V, Trotter T, Kwok YN, Nishimura E, Pederson R, Brown J: Effects of cysteamine on secretion of gastrin and somatostatin from the rat stomach. Gastroenterology 86:834–838, 1984

    Google Scholar 

  13. Szabo S, Haith LR, Reynolds ES: Pathogenesis of duodenal ulceration produced by cysteamine or propionitrile. Influence of vagotomoty, sympathectomy, histamine depletion, H-2 receptor antagonists and hormones. Dig Dis Sci 24:471–478, 1979

    Google Scholar 

  14. Kim KH, Kim HY, Lee GY, Hong SS: Involvement of histamine release in the mechanism of cysteamine-induced gastric hypersecretion. Arch Int Pharmacodyn 276:279–286, 1985

    Google Scholar 

  15. Szabo S, Horner HC, Maull H, Schnoor J, Chiueh CC, Palkovits M: Biochemical changes in tissue catecholamines and serotonin in duodenal ulceration caused by cysteamine or propionitrile in the rat. J Pharmacol Exp Ther 240:871–878, 1987

    Google Scholar 

  16. Arai I, Hirose-Kijma H, Usuki-Ito C, Muramatsu M, Otomo S: Putative role of endogenous insulin in cysteamine-induced hypersecretion of gastric acid in rats. Eur J Pharmacol 202:213–219, 1991

    Google Scholar 

  17. Szabo S, Reichlin S: Multi-organ depletion of somatostatin caused by the duodenal ulcerogen cysteamine. Regul Pep 1,Suppl 1:S-111, 1980

    Google Scholar 

  18. Black HE: The effects of steroids upon the gastrointestinal tract. Toxicol Pathol 16:213–222, 1988

    Google Scholar 

  19. Morishige WK, Pepe GJ, Rothchild I: Serum luteinizing hormone, prolactin and progesterone levels during pregnancy in the rat. Endocrinology 92:1527–1530, 1973

    Google Scholar 

Download references

Authors
  1. Corrado Montoneri
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Filippo Drago
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Montoneri, C., Drago, F. Effects of Pregnancy in Rats on Cysteamine-Induced Peptic Ulcers (Role of Progesterone). Dig Dis Sci 42, 2572–2575 (1997). https://doi.org/10.1023/A:1018881016246

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1023/A:1018881016246

Search

Navigation