Skip to main content
SpringerLink
Log in

Effect of Gastrin-17 on Lower Esophageal Sphincter Characteristics in Man

  • Published:
Digestive Diseases and Sciences Aims and scope Submit manuscript

Abstract

We studied the effect of gastrin-17 on loweresophageal sphincter (LES) characteristics in man. Ninehealthy volunteers participated in two experimentsperformed in random order during continuous infusion of saline (control) or gastrin-17 (15pmol/kg/hr). LES pressure (LESP) and transient loweresophageal sphincter relaxations (TLESR), as most theimportant reflux mechanism, were measured withintraesophageal sleeve manometry combined with pH metry.Infusion of gastrin-17 resulted in plasma gastrin levelscomparable to those reached after a mixed meal. Duringcontinuous gastrin infusion, LESP decreasedsignificantly (P ≤ 0.05) compared to control. The rate andduration of TLESR was not influenced by gastrin-17.Gastroesophageal reflux and the number of TLESRassociated with reflux were significantly (P ≤ 0.05)increased during gastrin infusion. These results suggestthat in humans gastrin at physiological postprandialplasma concentrations decreases LESP, does not influenceTLESR, but increases the percentage of TLESR associated with reflux.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

REFERENCES

  1. Castell DO, Harris LD: Hormonal control of gastroesophageal-sphincter strength. N Engl J Med 282:886–889, 1970

    Google Scholar 

  2. Walker CO, Frank SA, Manton J, Fordtran JS: Effect of continuous infusion of pentagastrin on lower esophageal sphincter pressure and gastric acid secretion in normal subjects. J Clin Invest 56:218–225, 1975

    Google Scholar 

  3. Freeland GR, Higgs RH, Castell DO, McGuigan JE: Lower esophageal sphincter and gastric acid response to intravenous infusions of synthetic human gastrin I heptadecapeptide. Gastroenterology 71:570–574, 1976

    Google Scholar 

  4. Henderson JM, Lidgard G, Osborne DH, Carter DC, Heading RC: Lower oesophageal sphincter response to gastrin, pharmacological or physiological? Gut 19:99–102, 1978

    Google Scholar 

  5. Jensen DM, McCallum RW, Corazziari E, Elashoff J, Walsh JH: Human lower esophageal sphincter responses to synthetic human gastrins 34 (G-34) and 17 (G-17). Gastroenterology 79:431–438, 1980

    Google Scholar 

  6. Allescher HD, Stoschus B, Wunsch E, Schusdziarra V, Classen M: Effect of human gastrin-17 with and without acid suppression on human esophageal motility. Z Gastroenterol 33:385–391, 1995

    Google Scholar 

  7. Lepsien G, Dietrich K: Peptone stimulation of the lower esophageal sphincter in patients with reflux disease. Z Gastroenterol 26:209–216, 1988

    Google Scholar 

  8. Dent J, Holloway RH, Toouli J, Dodds WJ: Mechanisms of lower oesophageal sphincter incompetence in patients with symptomatic gastro-oesophageal reflux. Gut 29:1020–1028, 1988

    Google Scholar 

  9. Mittal RK, Holloway RH, Penagini R, Blackshaw LA, Dent J: Transient lower esophageal sphincter relaxation. Gastroenterology 109:601–610, 1995

    Google Scholar 

  10. Holloway RH, Kocyan FP, Dent J: Provocation of transient lower esophageal sphincter relaxations by meals in patients with symptomatic gastroesophageal reflux. Dig Dis Sci 36:1034–1039, 1991

    Google Scholar 

  11. Penagini R, Bartesaghi B, Conte D, Bianchi PA: Rate of transient lower oesophageal sphincter relaxations of healthy humans after eating a mixed nutrient meal: Time course and comparison with fasting. Eur J Gastroenterol Hepatol 4:35–38, 1992

    Google Scholar 

  12. Jansen JBMJ, Lamers CBHW: Effect of changes in serum calcium on secretin stimulated serum gastrin in patients with Zollinger-Ellison syndrome. Gastroenterology 83:173–178, 1982

    Google Scholar 

  13. Ouyang A, Cohen S: Effects of hormones on gastrointestinal motility. Med Clin North Am 65:1111–1127, 1981

    Google Scholar 

  14. Dent J, Chir B: A new technique for continuous sphincter pressure measurement. Gastroenterology 71:263–267, 1976

    Google Scholar 

  15. Ledeboer M, Masclee AAM, Batstra MR, Jansen JB, Lamers CBHW: Effect of cholecystokinin on lower oesophageal sphincter pressure and transient lower oesophageal sphincter relaxations in humans. Gut 36:39–44, 1995

    Google Scholar 

  16. Boulant J, Fioramonti J, Dapoigny M, Bommelaer G, Bueno L: Cholecystokinin and nitric oxide in transient lower esophageal sphincter relaxation to gastic distension in dogs. Gastroenterology 107:1059–1066, 1994

    Google Scholar 

  17. Clavé P, González A, Martin M, Moreno A, Cussó X, Farré A, Lluís F: Endogenous cholecystokinin (CCK) enhances postprandial gastroesophageal reflux in healthy volunteers. Gastroenterology 110:A1136, 1996

    Google Scholar 

  18. Holloway RH, Hongo M, Berger K, McCallum RW: Gastric distension: A mechanism for postprandial gastroesophageal reflux. Gastroenterology 89:779–784, 1985

    Google Scholar 

  19. Strader DB, Benjamin SB, Orbuch M, Lubensky TA, Gibril F, Weber C, Fishbeyn VA, Jensen RT, Metz DC: Esophageal function and occurrence of Barrett's esophagus in Zollinger-Ellison syndrome. Digestion 56:347–356, 1995

    Google Scholar 

Download references

Authors
  1. J. W. A. Straathof
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. C. B. H. W. Lamers
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. A. A. M. Masclee
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Straathof, J.W.A., Lamers, C.B.H.W. & Masclee, A.A.M. Effect of Gastrin-17 on Lower Esophageal Sphincter Characteristics in Man. Dig Dis Sci 42, 2547–2551 (1997). https://doi.org/10.1023/A:1018872814428

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1023/A:1018872814428

Search

Navigation