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Noninvasive Monitoring of Hemodynamic Changes in Acute Pancreatitis in Rabbits

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Abstract

Hemodynamic parameters of experimental acutenecrotizing pancreatitis (AP) were monitored by means ofechocardiography in rabbits. Left ventricular (LV)systolic and diastolic parameters were determined before and 1, 3, 6, 12, 18, and 24 hr afterinjection of taurocholic acid in the pancreatic duct inAP animals. Temporary LV dilatation was observed 6 hrafter the AP induction [LV end-diastolic (ED) diameter from 1.16 ± 0.04 to 1.22 ± 0.04cm, P < 0.05, ED volume from 2.98 ± 0.34 to3.57 ± 0.75 ml, P < 0.05] without decrease insystolic function. Cardiac output (CO) and stroke volume(StV) was increased in both groups 3 hr after the operation (from 0.53 ±0.15 to 0.71 ± 0.06 L/min, P < 0.05 in AP),but in the AP animals it remained high. However, 24 hrafter AP induction, both the CO and the StV weredecreased significantly. The LV diastolic function was impaired 1 hrafter AP induction, but had recovered after 12 hr. Inconclusion, an early diastolic impairment followed by LVenlargement could be noninvasively observed in experimental AP in rabbits.

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Authors
  1. Mariann Gyongyosi
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  2. Tamas Takacs
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  3. Laszlo Czako
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  4. Zoltan Jambrik
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  5. Krisztina Boda
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  6. Andras Farkas
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  7. Tamas Forster
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  8. Miklos Csanady
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Gyongyosi, M., Takacs, T., Czako, L. et al. Noninvasive Monitoring of Hemodynamic Changes in Acute Pancreatitis in Rabbits. Dig Dis Sci 42, 955–961 (1997). https://doi.org/10.1023/A:1018872616400

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