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Prevention of Duodenal Ulcer Recurrence with 15 mg Lansoprazole (A Double-Blind Placebo-Controlled Study)

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Abstract

Although eradication of Helicobacter pyloricures duodenal ulcer, some patients are not infected andothers are treatment failures. This randomized,double-blind, placebocontrolled study assessed the value of treatment with low-dose lansoprazole inpreventing duodenal ulcer recurrence. One hundredeighty-six patients with endoscopic documentation ofhealed duodenal ulcer received 15 mg/day lansoprazole or placebo for 12 months or until ulcer recurred.Endoscopy results, symptom assessment, and fasting serumgastrin levels were obtained at multiple time points.Densities of E, EC, and G cells were assessed by biopsy when the ulcer recurred or at thefinal visit. Time to ulcer recurrence was significantlylonger (P < 0.001) in the lansoprazole group (median>12 months) compared to placebo (median <3months), and patients taking lansoprazole wereasymptomatic longer (P < 0.05). Maintenance therapywith lansoprazole 15 mg/day suppresses acid and controlsrecurrence of duodenal ulcer disease.

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Authors
  1. Frank Lanza
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  2. John Goff
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  3. David Silvers
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  4. Joan Winters
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  5. Nirag Jhala
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  6. Dennis Jennings
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  7. Pamela Greski-Rose
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Lanza, F., Goff, J., Silvers, D. et al. Prevention of Duodenal Ulcer Recurrence with 15 mg Lansoprazole (A Double-Blind Placebo-Controlled Study). Dig Dis Sci 42, 2529–2536 (1997). https://doi.org/10.1023/A:1018868713520

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