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Effect of Cholecystokinin Octapeptide and Atropine on Human Colonic Motility, Tone, and Transit

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Abstract

The role of cholecystokinin (CCK) inpostprandial control of colonic motility iscontroversial. To test the hypothesis that CCKstimulates colonic tone, motility, and transit wemeasured these colonic functions in 16 healthy subjects using intraluminalmanometry, barostatic balloon measurements, andradioscintigraphy. This was a randomized-order,double-blind, sequential study design in each subject ofsaline and either atropine (0.01 mg/kg stat and 0.01mg/kg/hr by infusion) or CCK-octapeptide (OP, 30 ng/kgstat and 60 ng/kg/hr by infusion). Atropine was used ascontrol to demonstrate responsiveness of selected parameters of colonic motility. Atropinesignificantly reduced whole colon (change from fasting= 52 ± 11%) and left colon (change from fasting61 ± 8%) phasic pressure activity and transversecolon tone (change from fasting 159 ± 40%); CCK-OP had nosignificant effects on phasic contractility, tone ortransit. Thus, a CCK-OP infusion that maximallystimulates pancreatic exocrine secretion and gallbladdercontraction has no effect on motor function or transit inprepared colon of healthy subjects.

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REFERENCES

  1. Ford MJ, Camilleri M, Wiste JA, Hanson RB: Differences in colonic tone and phasic responses to a meal in the transverse and descending human colon. Gut 37:264–269, 1995

    Google Scholar 

  2. Fargeas MJ, Bassotti G, Fioramonti J, Bueno L: Involvement of different mechanisms in the stimulatory effects of cholecystokinin octapeptide on gastrointestinal and colonic motility in dogs. Can J Physiol Pharmacol 67:1205–1212, 1989

    Google Scholar 

  3. Hellstrom PM: Atropine and naloxone block the colonic contraction elicited by cholecystokinin and pentagastrin. Acta Physiol Scand 124:25–33, 1985

    Google Scholar 

  4. Liberge M, Arruebo MP, Bueno L: Role of hypothalamic cholecystokinin octapeptide in the colonic motor response to a meal in rats. Gastroenterology 100:441–449, 1991

    Google Scholar 

  5. Harvey RF, Read AE: Effect of cholecystokinin on colonic motility and symptoms in patients with the irritable-bowel syndrome. Lancet 1:1–3, 1973

    Google Scholar 

  6. Waller SL, Carvalhinhos A, Misiewicz JJ, Russell RI: Effect of cholecystokinin on colonic motility. Lancet 1:264, 1973

    Google Scholar 

  7. Lyrenas E, Abrahamsson H, Dotevall G: Failure of beta-adrenergic stimulation to affect cholecystokinin-stimulated sigmoid motility in man. Scand J Gastroenterol 20:1169–1174, 1985

    Google Scholar 

  8. Niederau C, Faber S, Karaus M: Cholecystokinin's role in regulation of colonic motility in health and in irritable bowel syndrome. Gastroenterology 102:1889–1898, 1992

    Google Scholar 

  9. Renny A, Snape WJ Jr, Sun EA, London R, Cohen S: Role of cholecystokinin in the gastrocolonic response to a fat meal. Gastroenterology 85:17–21, 1983

    Google Scholar 

  10. Kellow JE, Miller LJ, Phillips SF, Haddad AC, Zinsmeister AR, Charboneau JW: Sensitivities of human jejunum, ileum, proximal colon and gallbladder to cholecystokinin octapeptide. Am J Physiol 252:G345–G356, 1987

    Google Scholar 

  11. Mangel AW, Brazer SR, Smith JW, Fitz JG, Taylor IL: Inhibition of colonic motility by cholecystokinin. Ann Med 24:341–342, 1992

    Google Scholar 

  12. Ford MJ, Camilleri M, Hanson RB, Wiste JA, Joyner MJ: Hyperventilation, central autonomic control, and colonic tone in humans. Gut 37:499–504, 1995

    Google Scholar 

  13. Steadman CJ, Phillips SF, Camilleri M, Talley NJ, Haddad A, Hanson R: Control of muscle tone in the human colon. Gut 33:541–546, 1992

    Google Scholar 

  14. von der Ohe MR, Camilleri M, Kvols LK, Thomforde GM: Motor dysfunction of the small bowel and colon in patients with the carcinoid syndrome and diarrhea. N Engl J Med 329:1073–1078, 1993

    Google Scholar 

  15. Camilleri M, Zinsmeister AR: Towards a relatively inexpensive, noninvasive, accurate test for colonic motility disorders. Gastroenterology 103:36–42, 1992

    Google Scholar 

  16. Proano M, Camilleri M, Phillips SF, Brown ML, Thomforde GM: Transit of solids through the human colon: Regional quantification in the unprepared bowel. Am J Physiol 258:G856–G862, 1990

    Google Scholar 

  17. von der Ohe MR, Camilleri M, Thomforde GM, Klee GG: Differential regional effects of octreotide on human gastrointestinal motor function. Gut 36:743–748, 1995

    Google Scholar 

  18. Levinson S, Bhasker M, Gibson TR, Morin R, Snape WJ Jr: Comparison of intraluminal and intravenous mediators of colonic response to eating. Dig Dis Sci 30:33–39, 1985

    Google Scholar 

  19. Jones RD, Chan K, Roulson CJ, Brown AG, Smith ID, Mya GH: Pharmacokinetics of flumazenil and midazolam. Br J Anaesth 70:286–292, 1993

    Google Scholar 

  20. Thiruvengadam R, DiMagno EP: Inactivation of human lipase by proteases. Am J Physiol 255:G476–G481, 1988

    Google Scholar 

  21. Hopman WPM, Kerstens PJSM, Jansen JBMJ, Risenbusch G, Lamers CBHW: Effect of graded physiologic doses of cholecystokinin on gallbladder contraction measured by ultrasonography. Gastroenterology 89:1242–1247, 1985

    Google Scholar 

  22. Maton PN, Selden AC, Fitzpatrick ML, Chadwick VS: Infusion of CCK-octapeptide in man: Relation between plasma cholecystokinin concentrations and gallbladder emptying rates. Eur J Clin Invest 14:37–41, 1984

    Google Scholar 

  23. Walsh JH, Lamers CB, Valenzuela JE: Cholecystokinin-octapeptide immunoreactivity in human plasma. Gastroenterology 82:438–444, 1982

    Google Scholar 

  24. von der Ohe M, Hanson RB, Camilleri M: Comparison of simultaneous recordings of human colonic contractions by manometry and a barostat. Neurogastroenterol Motil 6:213–222, 1994

    Google Scholar 

  25. Bueno L: Involvement of brain CCK in the adaptation of gut motility to digestive status and stress: A review. J Physiol (Paris) 87:301–306, 1993

    Google Scholar 

  26. Gue M, Gleizes-Escala C, Del Rio-Lacheze C, Junien JL, Bueno L: Reversal of CRF-and dopamine-induced stimulation of colonic motility by CCK and igmesine (JO 1784) in the rat. Br J Pharmacol 111:930–934, 1994

    Google Scholar 

  27. Barone FC, Bondinell WE, Labosh TJ, White RF, Ormsbee HS: Cholecystokinin stimulates neuronal receptors to produce contraction of the canine colon. Life Sci 44:533–542, 1989

    Google Scholar 

  28. Wiley J, Owyang C: Participation of serotonin and substance P in the action of cholecystokinin on colonic motility. Am J Physiol 252:G431–G435, 1987

    Google Scholar 

  29. von der Ohe MR, Camilleri M, Carryer PW: A patient with localized megacolon and intractable constipation: Evidence for impairment of colonic muscle tone. Am J Gastroenterol 89:1867–1870, 1994

    Google Scholar 

  30. Wiley J, Tatum D, Keinath R, Owyang C: Participation of gastric mechanoreceptors and intestinal chemoreceptors in the gastrocolonic response. Gastroenterology 94:1144–1149, 1988

    Google Scholar 

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Authors
  1. Michael D. O'Brien
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  2. Michael Camilleri
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  3. George M. Thomforde
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  4. Julie A. Wiste
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  5. Russell B. Hanson
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  6. Alan R. Zinsmeister
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O'Brien, M.D., Camilleri, M., Thomforde, G.M. et al. Effect of Cholecystokinin Octapeptide and Atropine on Human Colonic Motility, Tone, and Transit. Dig Dis Sci 42, 26–33 (1997). https://doi.org/10.1023/A:1018868601475

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  • DOI: https://doi.org/10.1023/A:1018868601475

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