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Salivary Epidermal Growth Factor Plays a Role in Protection of Ileal Mucosal Integrity

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Abstract

The role of salivary epidermal growth factor(EGF) in the maintenance of ileal mucosal integrity wasstudied by evaluating the effects of sialoadenectomy onluminal EGF levels, ileal tissue resistance(Rt), and unidirectional flux of[51Cr]EDTA. Mice in groups 1 (SLX) and 2 (SLX+ EGF) were subjected to sialoadenectomy, while mice ingroups 3 (Sham) and 4 (Sham EGF) underwent a shamprocedure. All animals received normal diet and water, except that EGF(100 ng/ml) was added to water for SLX + EGF and Sham +EGF mice. At seven days after surgery, luminal EGFlevels in gastrointestinal segments and ileal R were significantly reduced by sialoadenectomy, whichwas prevented by EGF supplementation. Unidirectionalflux of [51Cr]EDTA was 6- to 22-fold greaterin the ileum of sialoadenectomized mice, which wasprevented by EGF administration. Results suggest thatsalivary EGF may be the major source of intestinal EGF,and it may play a role in maintenance of ileal mucosalintegrity.

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Authors
  1. R. K. Rao
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  2. D. W. Thomas
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  3. S. Pepperl
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  4. F. Porreca
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Rao, R.K., Thomas, D.W., Pepperl, S. et al. Salivary Epidermal Growth Factor Plays a Role in Protection of Ileal Mucosal Integrity. Dig Dis Sci 42, 2175–2181 (1997). https://doi.org/10.1023/A:1018855525989

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  • DOI: https://doi.org/10.1023/A:1018855525989

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