Digestive Diseases and Sciences

, Volume 42, Issue 12, pp 2463–2467 | Cite as

p53 Expression in Gastric Cancer (Clinicopathological Correlation and Prognostic Significance)

  • S.P. Monig
  • S. Eidt
  • T.K. Zirbes
  • D. Stippel
  • S.E. Baldus
  • H. Pichlmaier


For evaluation of the prognostic relevance ofp53 expression in gastric cancer, theimmunohistochemical tissue status of 133 primary gastriccancer patients was investigated for p53 expression andthe association between p53 tissue status andclinicopathological parameters was analyzed. P53immunoreactivity was detected in the nuclei of cancercells in 35 cases (26.3%). The nuclear p53immunoreaction was closely associated with tumor location, lymph nodemetastasis, and curability. Tumors with positive p53stain reactions frequently metastasized to lymph nodes(metastatic rate: 91.4%) in contrast to tumors with negative p53 stain reactivity (71.4%, P =0.021). Immunohistochemical analysis of primary gastriccancer appears to be an accurate and simple method ofscreening for p53 expression. In combination with common prognostic parameters, determination of p53tissue status might help to detect prognosticallyunfavorable subgroups of gastric cancerpatients.



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  1. 1.
    Feavon ER, Vogelstein BA: Genetic model for colorectal tumogenesis. Cell 61:759–767, 1990Google Scholar
  2. 2.
    Tahara E: Molecular mechanism of stomach carcinogenesis. J Cancer Res Clin Oncol 119:1–8, 1993Google Scholar
  3. 3.
    Finlay CA, Hinds PW, Levine AJ: The p53 protooncogene can act as a supressor of transformation. Cell 157:1083–1093, 1990Google Scholar
  4. 4.
    Soussi T, Legros Y, Lubin R, Ory K, Schlichtholz B: Multifactorial analysis of p53 alterations in human cancer: A review. Int J Cancer 57:1, 1994Google Scholar
  5. 5.
    Schneider PM, Casson AG, Levin B, Garewal HS, Hoelscher AH, Becker K, Dittler HJ, Cleary KR, Troster M, Siewert JR, Roth JA: Mutations of p53 in Barrett's esophagus and Barret's cancer: A prospective study of ninety-eight cases. J Thorac Cardiovasc Surg 111:323–333, 1996Google Scholar
  6. 6.
    Carneiro F, David L, Sobrinho-Simoes M, Seruca R, Nesland JM: Oncogenes and onco-suppressor genes in gastric cancer carcinoma. Surg Pathol 5(3):225–238, 1994Google Scholar
  7. 7.
    Seruca R, David L, Holm R, Nesland JM, Fangan BM, Castedo S, Sobrinho-Simoes M, Borresen AL: P53 mutations in gastric carcinomas. Br J Cancer 65:708–710, 1992Google Scholar
  8. 8.
    Lauren P: The two histological main type of gastric carcinoma: Diffuse and so-called intestinal type carcinoma. An attempt at a histo-clinical classification. Acta Pathol Microbiol Scand 64:31–34, 1965Google Scholar
  9. 9.
    Borrmann R: Geschwülste des Magens und Duodenums. Einteilung der Krebse nach der grob anatomischen Beschaffenheit. In Handbuch der speziellen pathologischen Anatomie und Histologie. F Henke, O Lubarsch (eds). Berlin, Springer-Verlag, 1926, p 4Google Scholar
  10. 10.
    Kim JH, Takahashi T, Chiba J, Park JG, Birren MJ, Roh JK, Delee H, Kim JP, Minna JD, Gazdar AF: Occurence of p53 gene abnormalities in gastric carcinoma tumors and cell lines. J Nat Cancer Inst 83(13):938–943, 1991Google Scholar
  11. 11.
    Starzynska T, Bromery M: Prognostic significance of p53 overexpression in gastric and colorectal carcinoma. Br J Cancer 66:558–562, 1992Google Scholar
  12. 12.
    Fushida S: Frequent p53 mutations in human gastric cancer cell lines. J Juzen Med Soc 101:147–154, 1992Google Scholar
  13. 13.
    Tamura G, Kihana T, Nomura K, Terada M, Sugimura T, Hirohashi S: Detection of frequent p53 gene mutations in primary gastric cancer by cell sorting and polymeras chain reaction single-strand conformation polymorphism analysis. Cancer Research 51:3056–3058, 1991Google Scholar
  14. 14.
    Martin HM, Filipe MI, Morris RW, Lane D, Silvestre F: P53 expression and prognosis on gastric carcinome. Int J Cancer 50:859–862, 1992Google Scholar
  15. 15.
    Yonemura Y, Fushida A, Tsugawa K, Ninomiya I, Fonseca L, Yamaguchi A, Miyazaki I, Urano T, Shiku H: Correlation of p53 expression and proliferative activity in gastric cancer. Anal Cell Pathol 5:277–288, 1993Google Scholar
  16. 16.
    Kakeji Y, Korenga D, Tsujitani S, Baba H, Anai H, Maehara Y, Sugimachi K: Gastric cancer with p53 overexpression has high potential for metastasising to lymph nodes. Br J Cancer 67:589–593, 1993Google Scholar
  17. 17.
    Ochiai A, Yamauchi Y, Hirohashi S: P53 mutations in the non-neoplastic mucosa of the human stomach showing intestinal metaplasia. Int J Cancer 69:28–33, 1996Google Scholar

Copyright information

© Plenum Publishing Corporation 1997

Authors and Affiliations

  • S.P. Monig
  • S. Eidt
  • T.K. Zirbes
  • D. Stippel
  • S.E. Baldus
  • H. Pichlmaier

There are no affiliations available

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